Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with K_is of 13 nM, 1.5 nM, and 0.97 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively.

Solid

Ki: 0.32 nM (hCRF1), 2.2 nM (rCRF2α), and 0.62 nM (mCRF2β)

Urocortin, rat induces cyclic AMP (cAMP) generation with EC₅₀ of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively in stably transfected Chinese hamster ovary cells.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature or refrigerated transportation.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

• [1]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.  [Information]

  [2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.  [Information]

  [3]. Perrin MH, et al. Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci. 1999 Oct 20;885:312-28.  [Information]