8-CPT-Cyclic AMP (sodium salt)|93882-12-3|(8-CPT-cAMP sodium; 8-(p-Chlorophenylthio)-cAMP sodium)-陌孚医药/Medlife

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8-CPT-Cyclic AMP (sodium salt) (Synonyms: 8-CPT-cAMP sodium; 8-(p-Chlorophenylthio)-cAMP sodium)

目录号: PC11845 纯度: ≥98%

CAS No. :93882-12-3

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中文名称	8-CPT-Cyclic AMP (sodium salt)
中文别名	8-(4-硫代氯苯基)腺苷-3'',5''-(环状)单磷酸钠盐;8-(4-硫代氯苯基)腺苷-3,5-(环状)单磷酸钠盐;8-(4-硫代氯苯基)腺苷-3',5'-环状磷酸钠;8-(4-硫代氯苯基)腺苷-3',5'-(环状)单磷酸钠盐
英文名称	8-CPT-Cyclic AMP (sodium salt)
英文别名	Adenosine,8-[(4-chlorophenyl)thio]-, cyclic 3',5'-(hydrogen phosphate), monosodium salt(9CI);8-(4-CHLOROPHENYLTHIO)- ADENOSINE-3',5'-CYCLIC -MONOPHOSPHATE;8-CPT-Cyclic AMP (sodium salt);sodium,(4aR,6R,7R,7aS)-6-[6-amino-8-(4-chlorophenyl)sulfanylpurin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol;8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate sodium salt;8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT;8-CPT cAMP;pCPT-cAMP;4H-Furo[3,2-d]-1,3,2-dioxaphosphorin,adenosine deriv.
Cas No.	93882-12-3
分子式	C₁₆H₁₄N₅O₆PScl-^.Na+
分子量	493.79
包装储存	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性	8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). 8-CPT-Cyclic AMP sodium is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC₅₀ of 0.9 μM. 8-CPT-Cyclic AMP sodium also inhibits PDE III and PDE IV with IC₅₀Epac and is a potent Epac activator.
性状	Solid
体外研究(In Vitro)	a-Fas and TNF-α/CHX induces neutrophil death rapidly (within 2 h) to at least 90%. The commonly used cAMP analog 8-pCPT-cAMP (0.7 mM) delays TNF- /CHX-induced and a-Fas-induced apoptosis. It is more efficient against apoptosis induced by TNF- /CHX than against a-Fas. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transportation.
储存方式	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Connolly BJ, et al. 8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). Biochem Pharmacol. 1992;44(12):2303-2306. [Information] [2]. Krakstad C, et al. cAMP protects neutrophils against TNF-alpha-induced apoptosis by activation of cAMP-dependent protein kinase, independently of exchange protein directly activated by cAMP (Epac). J Leukoc Biol. 2004;76(3):641-647. [Information]

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