( /-) BAYK8644;(±)-Bay K 8644;(±)BayK8644;(+/-)-BAY-K 8644;(1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)-phenyl]-3-pyridine carboxylic acid methyl ester;1,4-D;2-aziridinecarbonitrile;2-cyano-2-aziridine;AC1L3M8Z;AC1Q4RJZ;CHEMBL177264;CTK1C2552;methyl-1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)-pyridine-3-carboxylate;nitrile of aziridine-2-carboxylic acid;rac-Aziridin-2-carbonitril;BAYK8644;Bay K 8644
Cas No.
71145-03-4
分子式
C16H15N2O4F3
分子量
356.30
包装储存
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
生物活性
Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644. Bay K 8644 is a L-type Ca channel agonist with an EC50 of 17.3 nM. Bay K 8644 increases Ca influx through sarcolemmal Ca channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects.
性状
Solid
IC50 & Target[1][2]
L-type calcium channel
17.3 nM (EC50)
体外研究(In Vitro)
In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.