5786-21-0|Clozapine| AChR

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Clozapine HF 1854, 氯氮平, LX 100-129

目录号: PC22156 纯度: 99.93%

Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.

CAS No. :5786-21-0

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中文名称	Clozapine
中文别名	氯氮平;8-氯-11(4-甲基-1-哌嗪基)-5H-二苯并[B,E][1,4]二氮杂草;8-氯-11-(4-甲基-1-哌嗪基)-5H-二苯并[b,e][1,4]二氮杂卓;氯扎平;氯氮平杂质;氯氮平-D4;氯氮平 GMP;氯氮平 EP标准品;氯氮平 USP标准品;氯氮平标准品;氯氮平-D3;氯氮平-D8;氯氮平分离度用混合物 USP标准品;氯氮平分离度用混合物标准品;氯氮平峰鉴别 EP标准品;8-氯-11-(4-甲基-1-哌嗪基)-5H-二苯并[b,e][1,4]-二氮杂草;抗精神病;氯氮平(对照品)
英文名称	Clozapine
英文别名	clozapine;5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-;8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine;BRN 0764984;CCRIS 9171;Clorazil;Clozapin;Clozapina;3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine;Clozapine solution;HF 1854;clorazil clozapin clozapine;8-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;Clozapinum;CLOZARIL;Fazaclo;Iprox;Leponex;Lepotex;Klozapol;Asaleptin;Fazaclo ODT;Clozapinum [INN-Latin];Clozapina [INN-Spanish];LX 1;8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;Clozapine;Prestwick0_000350;CLOZAPINE [JAN];Lopac-C-6305;KBio3_000620;CLOZAPINE [USP MONOGRAPH];CHEBI:92657;HMS3402P12;Clozapina (INN-Spanish);CPD000058365;CLOZAPINE (VERSACLOZ) [VANDF];Clozapine (versacloz);SR-01000000096-5;NCGC00015254-06;KBio2_005735;HY-14539;Clozapine (mylan);KBioGR_001336;Opera_ID_482;8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine (Clozapine);NCGC00015254-04;LEX-123;C06924;Azaleptine;DivK1c_000343;CLOZAPINE (EP MONOGRAPH);Spectrum4_000898;BC164328;8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine( Clozepine );SBI-0050264.P004;NCGC00022902-07;6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,9,12,14-heptaene;8-Chloro-11-(4-methyl-1-piperazinyl)-10H-dibenzo[b,e][1,4]diazepine;CLOZAPINE (TEVA) [VANDF];AB00052158_15;DTXCID302855;CAS-5786-21-0;Clozapine (JAN/USP/INN);NINDS_000343;BDBM50001884;Clozapine 1.0 mg/ml in Acetonitrile;8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;HB1607;LP00276;KBio3_000619;NC00667;Pharmakon1600-01500685;CLOZAPINE [HSDB];CLOZAPINE (UDL) [VANDF];H10436;SCHEMBL33323;MLS001077282;J60AR2IKIC;KBio1_000343;HMS3266A10;5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-;BCP25196;CLOZAPINE (MYLAN) [VANDF];NCGC00015254-13;AB00052158-13;NCGC00015254-11;5786-21-0;NSC 757429;Q221361;HMS3678F09;CLOZAPINE [INN];NCGC00015254-05;NCGC00015254-17;UNII-J60AR2IKIC;Spectrum3_001828;NCGC00015254-07;EN300-52510;Clozapine (udl);CS-0644;Clozapine (USAN:USP:INN:BAN);CLOZAPINE [USAN];CHEBI:3766;DB00363;Clozapine, 1mg/ml in Methanol;Clozapine (caraco);Clozapine for peak identification;3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine;HMS3260H14;Tox21_500276;Tox21_110113;NCGC00015254-03;CLOZAPINE (IVAX) [VANDF];CHEMBL42;8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;NCGC00015254-12;SR-01000000096;Bio1_000925;Bio2_000790;HMS1921C16;NCGC00015254-10;CLOZAPINE [VANDF];Clozapine (fazaclo);Clozapinum (INN-Latin);SPBio_002340;LX 100-129;NCGC00260961-01;L013417;3-chloro-6-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Clopazine);HMS2089L13;AB00052158_16;Versacloz;CLOZAPINE (FAZACLO) [VANDF];AKOS026749900;N05AH02;HMS20...
Cas No.	5786-21-0
分子式	C₁₈H₁₉ClN₄
分子量	326.82
包装储存	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.

产品详情	Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.
生物活性	Clozapine减少独立于前脉冲抑制的大鼠阿朴吗啡治疗.Clozapine显示出'倒U'形的剂量-反应曲线,扭转阿朴吗啡引起的损耗前脉冲抑制. Clozapine以浓度依赖性方式明显促进NMDA诱发的反应（EC50：14 nM）。Clozapine产生兴奋性突触后电位,被谷氨酸受体拮抗剂阻断,这表明这些兴奋性突触后电位是增加的兴奋性氨基酸的释放的结果。Clozapine是毒蕈碱M4受体的完全激动剂,EC50=11 nM,对forskolin刺激的cAMP累积产生抑制作用。Clozapine对其它4种毒蕈碱受体亚型的激动剂诱导的反应有强效拮抗作用。
储存方式	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
描述&特点	Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.
参考文献	1.Xu Z, Guo L, Yu J, et al.Ligand recognition and G protein coupling of trace amine receptor TAAR1.Nature.2023: 1-3.

溶解度数据	DMSO: 70 mg/mL (214.19 mM), Sonication is recommended. 2eq.HCl: 16.3 mg/mL (50 mM)), Heating is recommended.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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