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Amiodarone-d10 hydrochloride Synonyms: 胺碘酮-d10

目录号: PC22145 纯度: 98.81%

Amiodarone-d₁₀ (hydrochloride) 是 Amiodarone 的氘代物。Amiodarone 是一种抗心律失常剂，用于抑制 ATP 敏感性钾通道，IC₅₀ 为 19.1 μM。

CAS No. :1951-25-3

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中文名称	Amiodarone-d10 hydrochloride
中文别名	胺碘酮;乙胺碘呋酮;乙碘酮;安律酮;胺碘达隆;氘代呋喃丹;2-丁基-3-苯并呋喃基-4-[2-(二乙氨基)乙氧基-3,5-二碘苯基]甲酮
英文名称	Amiodarone
英文别名	(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanone;Amiodarone Base;Methanone, (2-butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)-;(2-Butylbenzofuran-3-yl)(4-(2-(diethylamino)-ethoxy)-3,5-diiodophenyl)methanone;Amiodarone;(2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine;2-butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran;2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone;AMidorone;amiodarona;Amiodarons;Atlansil;Cordarone;Sedacoron;Sedacorone;Tranquerone;2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone;Lopac-A-8423;(2-butylbenzofuran-3-yl)-[4-(2-diethylaminoethoxy)-3,5-diiodo-phenyl]-methanone;DTXCID702592;(2-butyl-1-benzofuran-3-yl)-[4-(2-diethylaminoethoxy)-3,5-diiodophenyl]methanone;(2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone;NCGC00024242-06;DB01118;NCGC00015096-06;AKOS005462717;NCGC00015096-03;Ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl;NCGC00015096-01;L001174;D02910;Spectrum3_001050;Bio2_000774;AB00053422-17;Spectrum4_001190;2-Butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl)benzofuran;KBioGR_001859;Amiodarona;NCGC00015096-04;Prestwick1_000409;(2-n-butyl-3-benzofuranyl) [4-[2-(diethylamino)ethoxyl]-3,5-diiodophenyl] methanone;L 3428;Amiodarone [USAN:INN:BAN];Labaz (Salt/Mix);KBio2_005430;GTPL2566;Bio2_000294;SBI-0050110.P003;HMS2089C07;CAS-1951-25-3;Spectrum5_001533;NCGC00015096-13;cid_441325;Amidorone;(2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone;KBio3_001800;2-Butyl-3-benzofuranyl p-((2-diethylamino)ethoxy)-m,m-diiodophenyl ketone;KBioSS_000741;AMIODARONE [MART.];Amiodaronum (INN-Latin);Spectrum2_001813;HY-14187;1951-25-3;HMS1989O16;Methanone, (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-;Amiodarona [INN-Spanish];KBio2_000294;(2-Butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diidophenyl)methanone;CCG-204217;CBiol_001740;IDI1_034044;AMIODARONE [WHO-DD];W-107695;KBioSS_000294;2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone;NCGC00015096-17;F2173-1018;C01BD01;CHEMBL633;AmiodaroneHCl;CHEBI:2663;NCGC00015096-02;{2-[4-(2-butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]ethyl}diethylamine;CAS-19774-82-4;Spectrum_000261;BDBM18957;CRD - Cardiac mixture;SDCCGSBI-0050110.P004;KBioGR_000294;BSPBio_000338;BPBio1_000372;AB00053422_18;KBio2_003309;Cordarone (Salt/Mix);NCGC00024242-03;Prestwick0_000409;UNM000001215003;Aratac;(2-butyl-1-benzofuran-3-yl)(4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl)methanone;(2-butylbenzofuran-3-yl)-[4-(2-diethylaminoethyloxy)-3,5-diiodo-phenyl]methanone;Amiodaronum [INN-Latin];BSPBio_002580;NINDS_000079;EN300-708787;HMS1791O16;AMIODARONE [USAN];NCGC00024242-05;BAA95125;IDI1_000079;C06823;UNII-N3RQ532IUT;2-...
Cas No.	1951-25-3
分子式	C₂₅H₂₉NO₃I₂
分子量	645.31
包装储存	4°C, sealed storage, away from moisture

产品详情	Amiodarone-d10 (hydrochloride) 是 Amiodarone 的氘代物。Amiodarone 是一种抗心律失常剂，用于抑制 ATP 敏感性钾通道，IC50 为 19.1 μM。
生物活性	Amiodarone-d10 (hydrochloride) is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2].
性状	固体
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture
描述&特点	Amiodarone-d10 (hydrochloride) 是 Amiodarone 的氘代物。Amiodarone 是一种抗心律失常剂，用于抑制 ATP 敏感性钾通道，IC50 为 19.1 μM。
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67. [3]. Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44.

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