GSK 690 (Hydrochloride) 是赖氨酸特异性去甲基化酶1 (LSD1) 的可逆抑制剂，K_d 值为 9 nM，IC₅₀ 值为 37 nM。

GSK 690 (Hydrochloride) is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a K d value of 9 nM and a biochemical IC 50 of 37 nM.

Solid

IC50: 37 nM (LSD1), Kd: 8 nM (LSD1).

GSK690 (1-10 μM) acts together with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells).
GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.
GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1?μM GSK690 for RD cells and 10?μM GSK690 for RH30 cells.
The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest .
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

[1]. Mould DP, et al. Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2017 Oct 12;60(19):7984-7999.
[2]. Haydn T, et al. Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells. Cell Death Dis. 2017 Jun 15;8(6):e2879.

In Vitro: DMSO : 125 mg/mL (307.94 mM; Need ultrasonic)配制储备液