JQKD82 trihydrochloride||-陌孚医药/Medlife

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JQKD82 trihydrochloride

目录号: PL15103 纯度: ≥99%

商品编号	规格	价格	会员价
PL15103-5mg	5mg	¥8407.27	请登录
PL15103-10mg	10mg	¥13600.00	请登录
PL15103-50mg	50mg	询价	询价
PL15103-100mg	100mg	询价	询价

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中文名称	JQKD82 trihydrochloride
英文名称	JQKD82 trihydrochloride
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	JQKD82 (JADA82) trihydrochloride 是一种细胞通透性和选择性 KDM5 抑制剂。JQKD82 trihydrochloride 增加 H3K4me3，可用于多发性骨髓瘤的研究。
生物活性	JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma.
性状	Solid
体外研究(In Vitro)	JQKD82 (0.3 μM; 24 hours) trihydrochloride causes an increase in the global H3K4me3 level of MM.1S cells. JQKD82 (0.1-10 μM; day 1-day 5) trihydrochloride inhibits the growth of MM.1S cells in a dose- and time-dependent manner. JQKD82 trihydrochloride is potent at eliciting growth suppression in MM.1S cells (IC50=0.42 μM). JQKD82 (1 μM; 24 hours) trihydrochloride induces G1 cell-cycle arrest by 48 hours in MM.1S and MOLP-8 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	JQKD82 (50-75 mg/kg; i.p.; twice a day for 3 weeks) trihydrochloride has anti-multiple myeloma activity. JQKD82 trihydrochloride displays an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Jun Qi, et al. Histone demethylase 5 inhibitors and uses thereof. WO2020033377A1.

溶解度数据	In Vitro: DMSO : 50 mg/mL (81.97 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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