NCGC00247743|1435192-04-3|-陌孚医药/Medlife

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NCGC00247743

目录号: PL15091 纯度: ≥98%

CAS No. :1435192-04-3

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中文名称	NCGC00247743
中文别名	化合物 T12193
英文名称	NCGC00247743
英文别名	NCGC00247743;Benzamide, N-[6-(dimethylamino)hexyl]-3-(8-hydroxy-6-quinolinyl)-
Cas No.	1435192-04-3
分子式	C₂₄H₂₉N₃O₂
分子量	391.51
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	NCGC00247743 是一种组蛋白赖氨酸脱甲基酶 KDM4 抑制剂。
生物活性	NCGC00247743 is a histone lysine demethylase KDM4 inhibitor.
性状	Solid
IC50 & Target[1][2]	KDM4
体外研究(In Vitro)	Based on structure-activity relationship studies, a series of chemical compounds are derived from 8-hydroxyquinoline (8HQ) and shown to be active inhibitors of KDM4E and KDM4A. The effect of these compounds is tested on the growth of LNCaP cells and NCGC00247751 (A1), NCGC00244536 (B3), and NCGC00247743 (I9) are selected. These inhibitors inhibit LNCaP cell growth with IC50s in the μM range. These compounds also inhibit the enzymatic activity of other KDM4 isoforms although, interestingly, the potency and efficacy of B3 and A1 for KDM4A, 4C, and 4D are lower compared to that of NCGC00247743 (I9), suggesting a potential selectivity of the inhibitors for different isoforms of KDM4. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Duan L, et al. KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. Chem Biol. 2015 Sep 17;22(9):1185-96.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (159.64 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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