S2101|1239262-36-2|-陌孚医药/Medlife

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S2101

目录号: PL15101 纯度: ≥99%

CAS No. :1239262-36-2

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产品详情	S2101 是一个赖氨酸特异性去甲基化酶 1 (LSD1) 抑制剂，其 IC₅₀ 值为 0.99 μM， K_i 值为 0.61 μM，K_inact/K_i 值为 4560 M/s。
生物活性	S2101 is a lysine-specific demethylase 1 (LSD1) inhibitor with an IC 50 of 0.99 μM, K i of 0.61 μM and K inact /K i of 4560 M/s.
性状	Solid
IC50 & Target[1][2]	KDM1/LSD1
体外研究(In Vitro)	S2101 is a lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 0.99 μM, Ki of 0.61 μM and Kinact/Ki of 4560 M/s. S2101 also displays much lower inhibition activity toward MAO-B (Ki=17 μM, Kinact/Ki=18 M/s) and MAO-A (Ki=110 μM, Kinact/Ki=60 M/s). The treatment of HEK293T cells with S2101 results in a dose-dependent increase in the level of H3K4me2, which must have accumulated by the inactivation of LSD1. During the course of S2101 treatment, the amounts of histone H3 and LSD1 in the nuclear extracts remain essentially unaffected. Because the treatment with 1 μM S2101 generates a level of H3K4me2 similar to that elicited by 50 μM 2-PCPA, S2101 is assumed to have approximately 50-fold stronger LSD1 inhibition activity than 2-PCPA in human cells.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Mimasu S, et al. Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1 . Biochemistry. 2010 Aug 3;49(30):6494-503.

溶解度数据	In Vitro: DMSO : 100 mg/mL (320.77 mM; ultrasonic and warming and heat to 60°C)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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