QC6352|1851373-36-8|-陌孚医药/Medlife

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QC6352

目录号: PL15121 纯度: ≥98%

CAS No. :1851373-36-8

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中文名称	QC6352
中文别名	QC6352
英文名称	QC6352
英文别名	QC6352
Cas No.	1851373-36-8
分子式	C₂₄H₂₅N₃O₂
分子量	387.47
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	QC6352 是一种具有口服活性、选择性的 KDM4C 抑制剂，其 IC₅₀ 值为 35 nM。
生物活性	QC6352 is an orally available, selective and potent KDM4C inhibitor with an IC 50 of 35 nM.
性状	Solid
IC50 & Target[1][2]	KDM4
体外研究(In Vitro)	QC6352 is a potent KDM4C inhibitor with an IC50 of 35±8 nM. In a concentration-dependent manner QC6352 dramatically reduces the anchorage-independent sphere-forming capacity of BCSC1 and BCSC2. QC6352 blocks proliferation and self-renewal of BCSCs. As shown by western blot analysis the protein levels of (Epidermal growth factor receptor) EGFR are reduced in both BCSC1 and BCSC2 upon treatment with QC6352. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	QC6352 strongly affects tumor growth and final tumor weight of both BCSC1 and BCSC2 xenografts. Treatment with QC6352 is well tolerated and does not affect body weight of the mice. Results demonstrate that treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Chen YK, et al. Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models. ACS Med Chem Lett. 2017 Jul 27;8(8):869-874. [2]. Metzger E, et al. KDM4 inhibition targets breast cancer stem-like cells. Cancer Res. 2017 Sep 7. pii: canres.1754.

溶解度数据	In Vitro: DMSO : 16.67 mg/mL (43.02 mM; Need ultrasonic)配制储备液

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