DDP-38003 trihydrochloride||-陌孚医药/Medlife

您当前的位置：

DDP-38003 trihydrochloride

目录号: PL15099 纯度: ≥98%

商品编号	规格	价格	会员价
PL15099-1mg	1mg	¥1112.73	请登录
PL15099-5mg	5mg	¥2101.82	请登录
PL15099-10mg	10mg	¥3585.45	请登录
PL15099-50mg	50mg	¥13600.00	请登录
PL15099-100mg	100mg	¥23490.91	请登录
PL15099-200mg	200mg	询价	询价
PL15099-500mg	500mg	询价	询价
PL15099-10mM*1mLinDMSO	10mM*1mLinDMSO	¥2126.55	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	DDP-38003 trihydrochloride
英文名称	DDP-38003 trihydrochloride
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	DDP-38003 trihydrochloride是新颖，有口服活性的 KDM1A/LSD1 抑制剂，IC₅₀值为84 nM。
生物活性	DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC 50 of 84 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 84 nM (KDM1A/LSD1)
体外研究(In Vitro)	DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Vianello P, et al. Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent. J Med Chem. 2016 Feb 25;59(4):1501-17.

溶解度数据	In Vitro: DMSO : 100 mg/mL (217.47 mM; Need ultrasonic)H₂O : 50 mg/mL (108.73 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation