HSDVHK-NH2 是整合素 αvβ3-玻璃体结合蛋白的互作抑制剂，其 IC₅₀ 值为 1.74 pg/mL (2.414 pM)。

HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC 50 of 1.74 pg/mL (2.414 pM).

Solid

αvβ3 2.74 nM (IC50)

HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group.
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM.
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression.
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

HSDVHK-NH2

[1]. Yoonsuk Lee, et al. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J Biomol Screen. 2004 Dec;9(8):687-94.
[2]. Youngjin Choi, et al. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics. 2010 Jan;10(1):72-80.

In Vitro: H₂O : 250 mg/mL (346.85 mM; Need ultrasonic)配制储备液