Leukadherin-1|344897-95-6|-陌孚医药/Medlife

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Leukadherin-1

目录号: PL14870 纯度: ≥98.0%

CAS No. :344897-95-6

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中文名称	Leukadherin-1
中文别名	Leukadherin 1
英文名称	Leukadherin-1
英文别名	Leukadherin 1;4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid;LA1;Leukadhedrin 1;4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid;Leukadherin-1;BDBM8427;C22H26Cl2N2O11;AOB4116;SYN5137;BCP18444;s8306;STL372026;(Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid;4-(5-((3-Benzyl-4-oxo-2-th
Cas No.	344897-95-6
分子式	C₂₂H₁₅NO₄S₂
分子量	421.49
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Leukadherin-1 是特异性的白细胞表面整合素 CD11b/CD18 的激动剂。Leukadherin-1 可增加 CD11b/CD18 依赖性细胞对血纤蛋白原的粘附，EC₅₀为 4 μM。Leukadherin-1 增强白细胞对配体 (如 ICAM-1) 和血管内皮的粘附，从而减少白细胞跨内皮迁移和流入损伤部位。Leukadherin-1 抑制先天性炎症信号转导。
生物活性	Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC 50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling.
性状	Solid
体外研究(In Vitro)	Leukadherin-1 is a specific agonist of the leukocyte surface integrin CD11b/CD18 (αMβ2; CR3; Mac-1). Leukadherin‐1 pretreatment reduces secretion of interferon (IFN)‐γ, tumour necrosis factor (TNF) and macrophage inflammatory protein (MIP)‐1β by monokine‐stimulated NK cells. Leukadherin‐1 pretreatment also reduces secretion of IL‐1β, IL‐6 and TNF by Toll‐like receptor (TLR)‐2 and TLR‐7/8‐stimulated monocytes. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Leukadherin-1 (1 mg/kg; i.p.; twice daily for 14 days) is beneficial in preventing hyperoxia-induced neonatal lung injury, an experimental model of bronchopulmonary dysplasia (BPD). has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Jagarapu J, et al. Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats. Am J Respir Cell Mol Biol. 2015;53(6):793-801. [2]. Maiguel D, et al. Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci Signal. 2011;4(189):ra57.

溶解度数据	In Vitro: DMSO : 5 mg/mL (11.86 mM; Need ultrasonic)配制储备液

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