Angiotensin III, human, mouse|13602-53-4|-陌孚医药/Medlife

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Angiotensin III, human, mouse

目录号: PL13874 纯度: ≥99%

CAS No. :13602-53-4

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中文名称	Angiotensin III, human, mouse
中文别名	血管紧张素Ⅲ;血管紧张素III
英文名称	Angiotensin III, human, mouse
英文别名	2-8-Angiotensin II,5-L-isoleucine-;Angiotensin III;ACE INACTIVATOR;angiotensin I-converting enzyme;Angiotensin I-Converting Enzyme (ACE) Inactivator;ANGIOTENSIN I-CONVERTING ENZYME INACTIVATOR;angiotensin II (2-8);CYANOAC-PHE-PHE;CYANOAC-PHE-PHE-OH;H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH;human AngIII;N-[N-(cyanoacetyl)-L-phenylalanyl]-L-phenylalanine;N-< N-(cyanoacetyl)-L-phenylalanyl> -L-phenylalanine;RVYIHPF;ANGIOTENSIN III, HUMAN;angiotensin III, 5-Ile-;[DES-ASP1]-ANGIOTENSIN II;ARG-VAL-TYR-ILE-HIS-PRO-PHE;ANGIOTENSIN II HEPTAPEPTIDE;ANGIOTENSIN III ACETATE SALT;ANGIOTENSIN III (HUMAN, MOUSE);Angiotensin III, human, mouse
Cas No.	13602-53-4
分子式	C₄₆H₆₆N₁₂O₉
分子量	931.09
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Angiotensin III, human, mouse 是一种七肽，为血管紧张素 2 型受体 (AT₂R) 激动剂，对 AT₂R 和 AT₁R 的 IC₅₀ 值分别为 0.648 nM 和 21.1 nM。
生物活性	Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT 2 R) agonist, with IC 50 s of 0.648 nM and 21.1 nM for AT 2 R and AT 1 R, respectively.
性状	Solid
IC50 & Target[1][2]	IC50: 0.648 nM (AT2R), 21.1 nM (AT1R)
体外研究(In Vitro)	Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (U Na V), fractional excretion of sodium (FE Na ), and fractional excretion of lithium (FE Li ) in SD rat. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	RVYIHPF
Sequence	Arg-Val-Tyr-Ile-His-Pro-Phe
参考文献	[1]. Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. [2]. Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95.

溶解度数据	In Vitro: H₂O : 100 mg/mL (107.40 mM; Need ultrasonic)配制储备液

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