BIO-1211|187735-94-0|-陌孚医药/Medlife

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BIO-1211

目录号: PL13859 纯度: ≥99%

CAS No. :187735-94-0

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中文名称	BIO-1211
英文名称	BIO-1211
英文别名	BIO 1211;BIO-1211;(4-((2-Methylphenyl)aminocarbonyl)-aminophenyl)acetyl-Fibronectin CS-1 Fragment (1980-1983);(4-((2-METHYLPHENYL)AMINOCARBONYL)-AMINOPHENYL)ACETYL-LEU-ASP-VAL-PRO-OH
Cas No.	187735-94-0
分子式	C₃₆H₄₈N₆O₉
分子量	708.80
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	BIO-1211 是高度选择性的、具有口服活性的 α4β1 (VLA-4) 抑制剂，其对 α4β1 和 α4β7 的 IC₅₀ 值分别为 4 nM 和 2 μM。
生物活性	BIO-1211 is a highly selective and orally active α4β1 (VLA-4) inhibitor, with IC 50 values of 4 nM and 2 μM for α4β1 and α4β7, respectively.
性状	Solid
IC50 & Target[1][2]	α4β1 4 nM (IC50) α4β7 2 μM (IC50
体外研究(In Vitro)	BIO-1211 almostly exhibits no activity for α1β1, α5β1, α6β1, αLβ2 and αIIbβ3. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	BIO-1211 (5 and 10 mg/kg, orally, once every other day) results in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in EAE in a dose-independent manner. BIO-1211 exhibits a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
参考文献	[1]. L L Chen, et al. Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand. J Biol Chem. 1999 May 7;274(19):13167-75. [2]. Nourollah Ramroodi, et al. Prophylactic Effect of BIO-1211 Small-Molecule Antagonist of VLA-4 in the EAE Mouse Model of Multiple Sclerosis. Immunol Invest. 2015;44(7):694-712.

溶解度数据	In Vitro: DMSO : 250 mg/mL (352.71 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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