Angiotensin II human acetate|68521-88-0|(Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate)-陌孚医药/Medlife

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Angiotensin II human acetate (Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate)

目录号: PL13879 纯度: ≥99%

CAS No. :68521-88-0

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中文名称	Angiotensin II human acetate
中文别名	血管紧张素II;血管紧张素 II 醋酸盐;血管紧张素Ⅱ.人
英文名称	Angiotensin II human acetate
英文别名	acetic acid;Angiotensin II;ANGIOTENSIN II ACETATE;AngiotensinIIhuman;(3S)-3-amino-3-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S,2S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenyl-ethyl]carbamoyl;(3S)-3-amino-3-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S,2S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenyl-ethyl]carbamoyl]pyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxo-propan-2-yl]carbamoyl]-2-methyl-butyl]carbamoyl]-2-(4-hydroxyphenyl)ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-4-(diaminomethylideneamino)butyl]carbamoyl]propanoic acid;ANGIOTENSIN II ACETATE HUMAN;ANGIOTENSIN II ACETATE SALT;angiotensin ii human acetate;ANGIOTENSIN II HUMAN ACETATE SALT;ANGIOTENSIN II,HUMAN,SYNTHETIC;ANGIOTENSIN II,MASS SPEC STANDARD;ANGIOTENSIN,HUMAN;ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT;Human angiotensin II acetate salt;HYPERTENSIN II;Angiotensin II [USAN];Angiotensin II acetate (USAN);Angiotensin II acetate [USAN];Angiotensin II human (acetate);(Ile5)-Angiotensin II acetate;Ang II acetate;DRVYIHPF acetate;Giapreza (TN);Angiotensin II, 5-L-isoleucine-, acetate (salt);31L3HS630A;Angiotensin II, human acetate salt;Angiotensin II human acetate
Cas No.	68521-88-0
分子式	C₅₂H₇₅N₁₃O₁₄
分子量	1106.23
包装储存	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

产品详情

Angiotensin II human (Angiotensin II) acetate 是一种血管收缩剂，是肾素/血管紧张素系统的主要生物活性肽。Angiotensin II human acetate 在调节人类血压中起着核心作用，主要通过血管紧张素 II 与 G 蛋白偶联受体 (GPCRs)、血管紧张素II 1型受体 (AT1R) 和血管紧张素II 2型受体 (AT2R) 之间的相互作用来介导。Angiotensin II human acetate 刺激交感神经刺激，增加醛固酮生物合成和肾脏活动。Angiotensin II human acetate 诱导血管平滑肌细胞生长，增加成纤维细胞中 I 型和 III 型胶原的合成，导致血管壁和心肌增厚，并导致纤维化。Angiotensin II human acetate 也诱导细胞凋亡。Angiotensin II human acetate 通过 LOX-1 依赖的氧化还原敏感途径诱导内皮细胞毛细血管形成。

生物活性

Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 depend

性状

Solid

体外研究(In Vitro)

Most of the known actions of Angiotensin II (Ang II) human acetate are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function.
Angiotensin II human acetate raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II human acetate actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1).
Angiotensin II (1 nM) induces the expression of LOX-1 and VEGF and enhances capillary formation from human coronary endothelial cells in Mat

体内研究(In Vivo)

Angiotensin II human (5 mL of 1 nM; intraperitoneal injection; 200-250 g Sprague-Dawley rats) acetate induces a significant neutrophil recruitment that was maximal at 4 hours and had resolved by 24 hours.
To distinguish the AT 1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II human (1000 ng/kg/min) acetate continuously for 4 weeks. Angiotensin II human acetate causes hypertension by activating AT 1 receptors in the kidney promoting sodium reabsorption. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

ClinicalTrial

SequenceShortening

DRVYIHPF

Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

参考文献

[1]. de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.
[2]. Fyhrquist F, et al. Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. 1995 Nov;9 Suppl 5:S19-24.

溶解度数据	In Vitro: H₂O : 25 mg/mL (22.60 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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