Nicodicosapent|1269181-69-2|-陌孚医药/Medlife

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Nicodicosapent

目录号: PL14893 纯度: ≥98%

CAS No. :1269181-69-2

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中文名称	Nicodicosapent
英文名称	Nicodicosapent
英文别名	Nicodicosapent
Cas No.	1269181-69-2
分子式	C₂₈H₃₉N₃O₂
分子量	449.63
包装储存	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	Nicodicosapent 是一种脂肪酸烟酸共轭体，可以抑制固醇调节元件结合蛋白 (SREBP) 的活性，调节胆固醇代谢的蛋白质如 PCSK9，HMG-CoA reductase，ATP citrate lyase 和 NPC1L1 等的活性。
生物活性	Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
性状	Solid
体外研究(In Vitro)	Nicodicosapent decreases the production of mature SREBP-2 protein in HepG2 cells, but does not interact with the GPR109A receptor. Nicodicosapent shows a synergistic inhibition on secreted PCSK9 and has an IC50 value of 17 μM. Nicodicosapent significantly inhibits ApoB secretion in a dose-dependent manner with IC50 of 27 μM. Nicodicosapent results in a time-dependent hydrolysis in HepG2 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Nicodicosapent (100 mg/kg po) produces high plasma levels of nicotinuric acid in the plasma. ApoE*3-Leiden mice treated with Nicodicosapent show a significant reduction in PCSK9 levels, LDL particles including VLDL and LDL cholesterol, as well as plasma triglycerides. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Vu CB, et al. Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid. J Med Chem. 2016 Feb 11;59(3):1217-31.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (222.41 mM)Ethanol : 2 mg/mL (4.45 mM; Need ultrasonic)

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