Fatostatin|125256-00-0|(125B11)-陌孚医药/Medlife

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Fatostatin (Synonyms: 125B11)

目录号: PL14891 纯度: ≥99%

CAS No. :125256-00-0

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中文名称	Fatostatin
中文别名	4-[4-(4-甲基苯基)-2-噻唑基]-2-丙基吡啶;Fatostatin A;脂肪抑制素
英文名称	Fatostatin
英文别名	Fatostatin A;125B11;2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide(Fatostatin A);4-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-2-propylpyridine;1-(2,4-diaminophenylazo)naphthalene;1-naphthylamin-> m-phenylendiamin;2-propyl-4-(4-p-tolylthiazol-2-yl)pyridine;4-(1-naphthylazo)benzene-1,3-diamine;4-naphthalen-1-yl-diazenyl-benzene-1,3-diamine;C.I. 11285;C.I. Solvent Brown 1;Fat Brown RR;Hexatype Brown N;Lithofor Brown A;Resinol RRN;Solvent Brown 1;Sudan Brown RR;Sudan Brown YR;Typogen Brown N;2-Propyl-4-(4-(p-tolyl)thiazol-2-yl)pyridine;4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole;Fatostatin
Cas No.	125256-00-0
分子式	C₁₈H₁₈N₂S^.HBr
分子量	375.33
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Fatostatin (125B11) 是 SREBP 活化的特异性抑制剂，可抑制 SREBP-1 和 SREBP-2 的活化。Fatostatin 与 SCAP (SREBP裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。Fatostatin 降低了细胞中成脂基因的转录。Fatostatin 具有抗肿瘤作用，能降低 ob/ob 小鼠的高血糖。
生物活性	Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice.
性状	Solid
体外研究(In Vitro)	Fatostatin (125B11) (0.1-1 μM; 3 days) inhibits the androgen-independent prostate cancer cell proliferation (IC50=0.1 μM) in an independent of the known IGF1-signaling pathway. Fatostatin inhibits insulin-induced adipogenesis of 3T3-L1 cells. Fatostatin directly binds SCAP and blocks its ER-to-Golgi transport with IC50 of 2.5 and 10 μM in mammalian cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Fatostatin (125B11) (30 mg/kg; 150 μL; i.p. injection; daily for 28 days) reduces adiposity, ameliorated fatty liver by reducing triglyceride (TG) storage, and lowered hyperglycemia in ob/ob mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003 Feb 28;278(9):7320-4. [2]. Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28;16(8):882-92. [3]. Li X et al. Fatostatin

溶解度数据	In Vitro: DMSO : ≥ 27 mg/mL (91.71 mM)配制储备液

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