Angiotensin (1-7) (acetate)|2855063-75-9|(TXA127 acetate; Angiotensin (1-7) (acetate); Ang-(1-7) (acetate))-陌孚医药/Medlife

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Angiotensin (1-7) (acetate) (Synonyms: TXA127 acetate; Angiotensin (1-7) (acetate); Ang-(1-7) (acetate))

目录号: PL13882 纯度: ≥98%

CAS No. :2855063-75-9

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中文名称	Angiotensin (1-7) (acetate)
英文名称	Angiotensin (1-7) (acetate)
英文别名	HY-12403A;5-L-isoleucine-1-7-angiotensinII;CS-0163555;acetic acid;(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid;Angiotensin (1-7) (acetate);MS-31790;2855063-75-9
Cas No.	2855063-75-9
分子式	C₄₃H₆₆N₁₂O₁₃
分子量	959.06
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Angiotensin 1-7 (Ang-(1-7)) acetate 是肾素-血管紧张素系统 (RAS) 中的一种内源性七肽，由于其在心肌细胞中的抗炎和抗纤维化活性而具有心脏保护作用。Angiotensin 1-7 acetate 抑制纯化的犬血管紧张素转换酶 (ACE) 活性(IC₅₀=0.65 μM)。Angiotensin 1-7 acetate 通过抑制血管紧张素转换酶和释放一氧化氮作为激肽诱导的血管舒张的局部协同调节剂。Angiotensin 1-7 acetate 阻断血管紧张素 Ⅱ 诱导的平滑肌细胞增殖和肥大，对内皮细胞具有抗血管生成和生长抑制作用。
生物活性	Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC 50 =0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium.
性状	Solid
IC50 & Target[1][2]	IC50: 0.65 μM (ACE)
体外研究(In Vitro)	Angiotensin 1-7 (Ang-(1-7)) inhibits cultured vascular smooth muscle cell growth, whereas equal molar concentration of Ang II stimulates cell growth. Angiotensin 1-7 (Ang 1-7) abrogates the methylglyoxal-modified albumin (MGA)-stimulated myofibroblast phenotype by inhibiting the chronic stimulation of the TGF-β-ERK pathway in NRK-52E cells. Angiotensin 1-7 signals through the Mas receptor ( MasR) in opposition to Ang II/angiotensin II type 1 receptor (AT1R), promoting anti-inflammatory,vasodilatory, and neuroprotective effects. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Daily Angiotensin 1-7 (Ang-(1-7)) treatment (0.01-0.06 mg/kg) results in significant amelioration of DSS-induced colitis. Colitis-associated phosphorylation of p38, ERK1/2 and Akt is reduced by Ang 1-7 treatment. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	DRVYIHP
Sequence	Asp-Arg-Val-Tyr-Ile-His-Pro
参考文献	[1]. Gómez-Mendoza DP, et al. Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4. J Proteomics. 2019;208:103486. [2]. Li P, et al. Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide. Hypertension. 1997 Jan;29(1 Pt 2):394-400.

溶解度数据	In Vitro: H₂O : 62.5 mg/mL (65.17 mM; Need ultrasonic)配制储备液

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