FASN-IN-3|2097262-60-5|-陌孚医药/Medlife

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FASN-IN-3

目录号: PL14884 纯度: ≥98%

CAS No. :2097262-60-5

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中文名称	FASN-IN-3
中文别名	化合物FASN-IN-3;4-(1-(5-(3,4-二甲基-1H-吡唑-5-基0-2,4-二甲基苯甲酰基)氮杂环丁烷-3-基)苯甲腈
英文名称	FASN-IN-3
英文别名	FASN-IN-3;FASN inhibitor 1;Benzonitrile, 4-[1-[5-(3,4-dimethyl-1H-pyrazol-5-yl)-2,4-dimethylbenzoyl]-3-azetidinyl]-;4-(1-(5-(3,4-Dimethyl-1H-pyrazol-5-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile
Cas No.	2097262-60-5
分子式	C₂₄H₂₄N₄O
分子量	384.47
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	FASN-IN-3 是一种脂肪酸合酶 (FASN) 抑制剂，详细信息请参考专利文献 US20170119786A1 中的化合物 242A。
生物活性	FASN-IN-3 is a fatty acid synthase (FASN) inhibitor extracted from patent US20170119786A1, compound 242A.
性状	Solid
IC50 & Target[1][2]	FASN
体外研究(In Vitro)	Human PBMC and monocytes in cell cultures are stimulated with lipopolysaccharide (LPS), a Toll 4 receptor agonist, or lipoteichoic acid (LTA), a Toll 2 receptor agonist. Stimulation with either LPS or LTA plus DMSO, the solvent for FASN-IN-3 (Compound 242A), results in secretion of IL-1 beta. FASN inhibitor 1 treatment of PBMC, which is a mixed population of mononuclear cells including both lymphocytes and monocytes, reduces the level of IL-1 beta resulting from either LPS or LTA stimulation. For monocytes, FASN-IN-3 treatment reduces the level of IL-1 beta resulting from LTA stimulation whereas there is only a slight reduction after LPS stimulation. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Buckley, Douglas I, et al. HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS. US20170119786A1

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (86.69 mM; ultrasonic and warming and heat to 80°C)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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