Abciximab|143653-53-6|-陌孚医药/Medlife

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Abciximab

目录号: PL14850 纯度: ≥99%

CAS No. :143653-53-6

商品编号	规格	价格	会员价
PL14850-1mg	1mg	¥10880.00	请登录
PL14850-5mg	5mg	询价	询价
PL14850-10mg	10mg	询价	询价

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中文名称	Abciximab
中文别名	阿昔单抗;ABCIXIMAB ( 阿昔单抗 )
英文名称	Abciximab
英文别名	Immunoglobulin G1,anti-(human integrin aIIbb3) Fab fragment (human-mousemonoclonal c7E3 clone p7E3VHhCg1 g1-chain), disulfide withhuman-mouse monoclonal c7E3 clone p7E3VkhCk k-chain;ABCIXIMAB;Immunoglobulin G1,anti-(human integrin aIIbb3) Fab fragment (human-mousemonoclonal c7E3 clone ...;Immunoglobulin G1,anti-(human integrin aIIbb3) Fab fragment (human-mousemonoclonal c7E3 clone p7E3VHhCg1 g1-chain), disulfide;Abciximab [USAN:INN:BAN];C 7E3;CentoRx;ReoPro;Rheopro;Immunoglobulin G1, (human-mouse monoclonal c7E3 clone p7E3VHhCgamma1 Fab fragment anti-human glycoprotein IIb/IIIa receptor), disulfide with human-mouse monoclonal c7E3 clone p7E3VkappahCkappa light chain;Reopro;Unii-X85G7936gv;Research Grade Abciximab(DHC33301);Abciximab
Cas No.	143653-53-6
分子式	₀
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Abciximab (C7E3) 是一种小鼠/人嵌合单克隆抗体，是一种糖蛋白 IIb/IIIa (glycoprotein IIb/IIIa) 抑制剂。 Abciximab 通过与糖蛋白 IIb/IIIa、vitronectin 和 Mac-1 受体结合抑制血小板聚集和白细胞粘附。

生物活性

Abciximab (C7E3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors.

体外研究(In Vitro)

Abciximab (C7E3) inhibits platelet aggregation induced by physiologic and pathologic agonists by binding to the platelet αIIbβ3 integrin.
Abciximab appears to have similar affinity for the αIIbβ3 and αvβ3 integrins and redistributes between them. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Abciximab (C7E3) (0.25 mg/kg/day; i.v.; 28 days) effectively prevents neointimal hyperplasia. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats weighing 200-250 g, ball

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Ibbotson T, et al. Abciximab: an updated review of its therapeutic use in patients with ischaemic heart disease undergoing percutaneous coronary revascularisation. Drugs. 2003;63(11):1121-63.
[2]. Wu CH, et al. Mechanisms involved in the inhibition of neointimal hyperplasia by abciximab in a rat model of balloon angioplasty. Thromb Res. 2001 Feb 1;101(3):127-38.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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