4E1RCat|328998-25-0|-陌孚医药/Medlife

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4E1RCat

目录号: PL14817 纯度: ≥99%

CAS No. :328998-25-0

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中文名称	4E1RCat
中文别名	4-[2,3-二氢-3-[[5-(4-硝基苯基)-2-呋喃基]亚甲基]-2-氧代-5-苯基-1H-吡咯-1-基]苯甲酸;4E1RCat 抑制剂
英文名称	4E1RCat
英文别名	Benzoic acid,4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-;(E)-4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic;(E)-4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic Acid;4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid;4E1rcat;Benzoic acid,4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrro...;4E1RCat
Cas No.	328998-25-0
分子式	C₂₈H₁₈N₂O₆
分子量	478.45
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	4E1RCat 是一种 cap 依赖性翻译抑制剂，能够抑制 eIF4E:eIF4GI 相互作用，IC₅₀ 值约为 4 μM。
生物活性	4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC 50 an of ～4 μM.
性状	Solid
IC50 & Target[1][2]	eIF4
体外研究(In Vitro)	4E1RCat is an inhibitor of eIF4E:eIF4GI interaction, with an IC50 an of ～4 μM. 4E1RCat binding to eIF4E also interferes with eIF4G and 4E-BP binding. 4E1RCat inhibits ribosome recruitment to mRNA in a cap-dependent manner. 4E1RCat blocks the capped mRNA translation, and the translation is activated by CDK1/CYCB1. Nearly all new protein synthesis in both mitosis and interphase is cap-dependent and -sensitive to 4E1RCat treatment, in HeLa and U2OS cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	4E1RCat (15 mg/kg, i.p.) affacts chemosensitivity of PtenEμ-Myc tumors in mice. 4E1RCat (15 mg/kg, i.p.) sensitizes PtenEμ-Myc and Tsc2Eμ-Myc lymphomas to the cytotoxic effects of doxorubicin (Dxr), and 4E1RCat targets translation in mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Cencic R, et al. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1046-51. [2]. Shuda M, et al. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5875-82.

溶解度数据	In Vitro: DMSO : 18.33 mg/mL (38.31 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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