SBI-0640756|1821280-29-8|(SBI-756)-陌孚医药/Medlife

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SBI-0640756 (Synonyms: SBI-756)

目录号: PL14813 纯度: ≥99%

CAS No. :1821280-29-8

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中文名称	SBI-0640756
中文别名	EIF4G1抑制剂(SBI-0640756);(E)-6-氯-3-(3-(5-氟吡啶-3-基)丙烯酰基)-4-苯基喹啉-2(1H)-酮;化合物SBI-0640756
英文名称	SBI-0640756
英文别名	6-Chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one;AK00799313;6-Chloro-3-[3-(5-fluoropyridin-3-yl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one;SBI-756;SBI-0640756;BCP23633;WXC28029;s8181;SBI0640756;SBI 0640756;D80610;(E)-6-Chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one;6-chloro-3-[(E)-3-(5-fluoropyridin-3-yl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one;CID 121241171;(E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one;CS-2838;SBI 756;SBI756;2(1H)-Quinolinone,6-chloro-3-[(2E)-3-(5-fluoro-3-pyridinyl)-1-oxo-2-propen-1-yl]-4-phenyl-
Cas No.	1821280-29-8
分子式	C₂₃H₁₄ClFN₂O₂
分子量	404.82
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	SBI-0640756 (SBI-756) 是一种 eIF4G1 抑制剂，能够破坏 eIF4F 复合体。
生物活性	SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.
性状	Solid
IC50 & Target[1][2]	eIF4G1
体外研究(In Vitro)	SBI-0640756 (SBI-756) is a water soluble inhibitor of eIF4G1. SBI-0640756 (SBI-756) (0-1 μM) disrupts eIF4F complex in parent and BRAFi-resistant melanoma. SBI-0640756 (SBI-756) shows inhibitory effect on human melanoma lines, and also suppresses AKT, NF-κB and AKT/mTORC1 activity. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	SBI-0640756 (SBI-756) (0.5 mg/kg, i.p.) delays tumor onset and reduces tumor incidence by 50% in Nras/Ink4a genetic model. SBI-0640756 (SBI-756) (1 mg/kg, 2 times per week, i.p.) in combination with BRAF inhibitor potently suppresses growth of established tumors and does not resume tumor growth in immunodeficient mice bearing A375 tumors. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75(24):5211-8.

溶解度数据	In Vitro: DMSO : ≥ 26 mg/mL (64.23 mM)配制储备液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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