IDH1 Inhibitor 1|2234285-81-3|-陌孚医药/Medlife

您当前的位置：

IDH1 Inhibitor 1

目录号: PL14797 纯度: ≥99%

CAS No. :2234285-81-3

商品编号	规格	价格	会员价
PL14797-5mg	5mg	¥9643.64	请登录
PL14797-10mg	10mg	¥15454.55	请登录
PL14797-50mg	50mg	询价	询价
PL14797-100mg	100mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	IDH1 Inhibitor 1
英文名称	IDH1 Inhibitor 1
英文别名	IDH1 Inhibitor 1;BDBM50458777
Cas No.	2234285-81-3
分子式	C₂₀H₁₈F₄N₆O₂
分子量	450.39
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	IDH1 Inhibitor 1 是一种有效的，口服生物可利用的，脑渗透性，选择性突变 IDH1 抑制剂，抑制 IDH1^R132H，IDH1^R132C，和 IDH1^WT，IC₅₀ 分别为 0.021 μM, 0.045 μM, 和 2.52 μM。具有抗肿瘤活性。
生物活性	IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC 50 s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1, IDH1, and IDH1, respectively. Anticancer activity.
性状	Solid
IC50 & Target[1][2]	IC50: 0.021 μM (IDH1), 0.045 μM (IDH1), and 2.52 μM (IDH1)
体外研究(In Vitro)	IDH1 Inhibitor 1 (Compound 19) inhibits cellular HCT116-IDH1 with an IC50 of 0.039 μM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	IDH1 Inhibitor 1 (Compound 19) inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model. IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1 mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Zhao Q, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors. ACS Med Chem Lett. 2018 Jun 11;9(7):746-751.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (222.03 mM)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation