Angiotensin II 5-valine|58-49-1|(血管紧张素 Ⅱ 5-缬氨酸; Valine angiotensin II; 5-L-Valine angiotensin II)-陌孚医药/Medlife

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Angiotensin II 5-valine (Synonyms: 血管紧张素 Ⅱ 5-缬氨酸; Valine angiotensin II; 5-L-Valine angiotensin II)

目录号: PL14755 纯度: ≥99%

CAS No. :58-49-1

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中文名称	Angiotensin II 5-valine
中文别名	血管紧张素;醋酸血管紧张素 II ANGIOTENSINII ACETATE;[VAL5]-血管紧缩素 2;醋酸血管紧张素;醋酸血管紧张素 II Angiotensin II Acetate;胆维他;茴三硫;茴三硫, 醋酸血管紧张素;血管紧张素II,1 - (N-甲基)-5-L-异亮氨酸-8(D-2-苯基甘氨酸) - (9CI);[Val5]血管紧张素II;[Val5]-血管紧张素 II
英文名称	Angiotensin II 5-valine
英文别名	Angiotensin acetate;[VAL5]-ANGIOTENSIN II;[VAL5] ANGIOTENSIN II HUMAN;ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE;DRVYVHPF;L-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE;H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH;[val5]-angiotensin ii acetate hydrate;(Val?)-AngiotensinII;(Val5)-Angiotensin II;Desmopressin Acetate;(5-L-Val)-Angiotensin II;[Asp(1),Val(5)]angiotensin II;[Val5]-Angiotensin II acetate salt hydrate;-angiotensin II;5-L-Valine angiotensin II;ANGIOTENSIN II,5-L-VALINE;Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH;Valine angiotensin II;Alanine,N-[1-[N-[N-[N-[N-(N2-L-a-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-valyl]-L-histidyl]-L-prolyl]-3-phenyl-,L- (6CI,7CI);1-Asp-5-Val-angiotensin II;1-L-Asparticacid-5-valine-angiotensin II;1-a-L-Aspartic acid-5-L-valine-angiotensin II;11: PN: US6762167 SEQID: 19 unclaimed sequence;16: PN:WO0144270 SEQID: 19 claimed protein;17: PN: WO0143761SEQID: 19 claimed protein;17: PN: WO0155176 SEQID: 19 claimed protein;18: PN: WO0002905 SEQID: 19 claimedprotein;18: PN: WO0198325 SEQID: 19 claimed protein;19: PN: WO0056345 SEQID: 19 claimed sequence;23:PN: WO0069900 SEQID: 672 unclaimed sequence;23: PN: WO9958140 SEQID: 19 claimedsequence;24: PN: WO0069900 SEQID: 673 unclaimed sequence;4: PN: WO0187976PAGE: 16 unclaimed sequence;5-Valine-angiotensinII;Angiotensin II(Alligator mississippiensis);Angiotensin II (ox);Angiotensin II 5-valine;L-Aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine;L-Phenylalanine, N-[1-[N-[N-[N-[N-(N2-L-a-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-valyl-]-L-histidyl]-L-prolyl]-;11: PN: US20090227507 SEQID:20 unclaimed protein;178: PN: WO2008004992 SEQID: 42 unclaimedsequence;17: PN: US20080293634 SEQID: 24 unclaimed sequence;17: PN:WO02087504 SEQID: 19 claimed protein;19: PN: US20030130196SEQID: 19 claimed protein;[Val5] Angiotensin II, human
Cas No.	58-49-1
分子式	C₄₉H₇₀N₁₄O₁₁^.C₂H₄O₂
分子量	1091.22
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	Angiotensin II 5-valine 是血管紧张素受体 (angiotensin receptor) 的激动剂。
生物活性	Angiotensin II 5-valine is an agonist of angiotensin receptor.
性状	Solid
IC50 & Target[1][2]	Angiotensin receptor.
体内研究(In Vivo)	By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone. has not independently confirmed the accuracy of these methods. They are for re
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	DRVYVHPF
Sequence	Asp-Arg-Val-Tyr-Val-His-Pro-Phe
参考文献	[1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8.

溶解度数据	In Vitro: H₂O : 100 mg/mL (96.89 mM; Need ultrasonic)配制储备液

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