AX20017|329221-38-7|-陌孚医药/Medlife

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AX20017

目录号: PL14668 纯度: ≥99%

CAS No. :329221-38-7

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中文名称	AX20017
中文别名	AX20017
英文名称	AX20017
英文别名	Benzo[b]thiophene-3-carboxamide, 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-;2-(cyclopropanecarbonylamino)-2,3,3a,4,5,6,7,7a-octahydro-1-benzothiophene-3-carboxamide;AX 20017;Benzo[b]thiophene-3-carboxamide, 2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-;Benzo[b]thiophene-3-carboxamide,2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-;PknG Inhibitor;AX-20017;AX20017;2-[(cyclopropylcarbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide;2-(cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide;2-(cyclopropanecarboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide;2pzi;TimTec1_000400;Oprea1_658271;Oprea1_698996;HMS1535C04;HMS3604K13;HMS3674K07;BCP31476;BDBM50185119;STK124515;DB07398;B
Cas No.	329221-38-7
分子式	C₁₃H₁₆N₂O₂S
分子量	264.34
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	AX20017是蛋白激酶G (PknG) 的小分子抑制剂，IC₅₀ 值为 0.39 μM。
生物活性	AX20017 is a small-molecule protein kinase G (PknG) inhibitor with an IC 50 of 0.39 μM.
性状	Solid
IC50 & Target[1][2]	IC50: 0.39 μM (PknG)
体外研究(In Vitro)	The compound AX20017 inhibitor is bound deep within a narrow pocket formed by the inter lobe cleft of the PknG domain. The main chain Glu233:O and Val235:NH of PknG form hydrogen bonds with AX20017.AX20017 results in mycobacterial transfer to lysosomes and killing of the mycobacteria. AX20017 does not affect the human kinases, whereas the activity of PknG is effectively inhibited. AX20017 does not affect cellular morphology, membrane ruffling, or macropinocytosis. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Walburger A, et al. Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science. 2004 Jun 18;304(5678):1800-4. [2]. Santhi N, et al. Insights from the molecular docking of withanolide derivatives to the target protein PknG from Mycobacterium tuberculosis. Bioinformation. 2011;7(1):1-4.

溶解度数据	In Vitro: DMSO : 130 mg/mL (491.79 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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