Cecropin B
目录号: PL14629 纯度: ≥98%
CAS No. :80451-05-4
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中文名称
Cecropin B
中文别名
天蚕丝抗菌肽;抗菌肽B;抗菌肽 B
英文名称
Cecropin B
英文别名
Cecropin B (Platysamiacecropia antibacterial peptide) (9CI);Cecropin B;LYS-TRP-LYS-VAL-PHE-LYS-LYS-ILE-GLU-LYS-MET-GLY-ARG-ASN-ILE-ARG-ASN-GLY-ILE-VAL-LYS-ALA-GLY-PRO-ALA-ILE-ALA-VAL-LEU-GLY-GLU-ALA-LYS-ALA-LEU-NH2
Cas No.
80451-05-4
分子式
C176H302N52O41S
分子量
3834.67
包装储存
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
产品详情
Cecropin B 有着高水平的抗菌活性,且是一种有价值的肽类抗菌素。
生物活性
Cecropin B has high level of antimicrobial activity and is considered as a valuable peptide antibiotic.
性状
Solid
IC50 & Target[1][2]
CYP3
体外研究(In Vitro)
Cecropin B-induces NF-κB activation playing a pivotal role in the suppression of CYP3A29 through disrupting the association of the PXR/retinoid X receptor alpha (RXR-α) complex with DNA sequences. Cecropin B activates pig liver cells by interacting with TLRs 2 and 4, which modulated NF-κB-mediated signaling pathways. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
The wounds are moist with more exudation in C group, while that in other groups are dry without obvious exudation. The body temperature of the majority of the mice in each group is elevated, but the number of leucocytes in each group is lowered after operation. The quantity of bacteria in muscle in A group is obviously lower than that in M group and C group. The number of surviving mice after 4 PID in C group is evidently smaller than that in A and M groups( P<0. 05). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
SequenceShortening
KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL-NH2
Sequence
Lys-Trp-Lys-Val-Phe-Lys-Lys-Ile-Glu-Lys-Met-Gly-Arg-Asn-Ile-Arg-Asn-Gly-Ile-Val-Lys-Ala-Gly-Pro-Ala-Ile-Ala-Val-Leu-Gly-Glu-Ala-Lys-Ala-Leu-NH2
参考文献
[1]. Zhou X et al. Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway. Sci Rep. 2016 Jun 14
[2]. Ren HT et al. [The antibacterial effect of cecropin B on pseudomonas aeruginosa infection of wounds in mice]. Zhonghua Shao Shang Za Zhi. 2006 Dec;22(6):445-7.
溶解度数据
In Vitro: H2O : 66.67 mg/mL (17.39 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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