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产品总数：60957
| 中文名称 |
Hydroxy Itraconazole
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|---|---|
| 中文别名 |
羟基伊曲康唑;羟基伊曲康唑(伊曲康唑代谢物);羟基伊曲康唑标准品;伊曲康唑羟基;羟基基伊曲康唑;依曲康唑杂质;伊曲康唑杂质1;伊曲康唑代谢物;伊曲康唑2-羟基代谢物
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| 英文名称 |
Hydroxy Itraconazole
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| 英文别名 |
3H-1,2,4-Triazol-3-one,4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-;HYDROXY ITRACONAZOLE;3H-1,2,4-Triazol-3-one,4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-;Itraconazole metabolite Hydroxy Itraconazole;R 63373;Itraconazole Impurity 1;Itraconazole 2-Hydroxy Metabolite;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)-;3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one
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| Cas No. |
112559-91-8
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| 分子式 |
C35H38N8O5Cl2
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| 分子量 |
721.63
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| 包装储存 |
4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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| 产品详情 |
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) 是 Itraconazole (ITZ) 的活性代谢物，Itraconazole 是一种三唑类抗真菌剂。
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|---|---|
| 生物活性 |
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
Antifungal
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| 体外研究(In Vitro) |
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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| 参考文献 |
[1]. Mino Y, et al. Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole. Clin Chim Acta. 2013 Jan 16;415:128-32.
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| 溶解度数据 |
In Vitro: DMSO : 100 mg/mL (138.58 mM; Need ultrasonic)H2O : 1 mg/mL (1.39 mM; ultrasonic and warming and heat to 80°C)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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