Neticonazole hydrochloride|130773-02-3|-陌孚医药/Medlife

您当前的位置：

Neticonazole hydrochloride

目录号: PL14614 纯度: ≥99%

CAS No. :130773-02-3

商品编号	规格	价格	会员价
PL14614-25mg	25mg	¥803.64	请登录
PL14614-50mg	50mg	¥1174.55	请登录
PL14614-100mg	100mg	¥1978.18	请登录
PL14614-200mg	200mg	询价	询价
PL14614-500mg	500mg	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Neticonazole hydrochloride
中文别名	盐酸奈康唑;盐酸奈替康唑;盐酸萘康唑
英文名称	Neticonazole hydrochloride
英文别名	1H-Imidazole,1-[(1E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-, hydrochloride (1:1);1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole,hydrochloride;(E)-(1-(2-Pentyloxyphenyl)-1-imidazolyl-2-methylthio)ethylene hydrochloride;(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)ethenyl)-1H-imidazole monohydrochloride;1-{(E)-2-(methylsulfanyl)-1-[2-(pentyloxy)phenyl]ethenyl}-1H-imidazole hydrochloride;1H-Imidazole, 1-(2-(methylthio)-1-(2-(pentyloxy)phenyl)ethenyl)-, monohydrochloride, (E)-;Neticonazole HCl;Neticonazole hydrochloride;SS 717;SS-717;Atolant;1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride
Cas No.	130773-02-3
分子式	C₁₇H₂₂N₂Os^.HCl
分子量	338.90
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Neticonazole hydrochloride 是一种咪唑衍生物，也是一种有效且长效的抗真菌剂。Neticonazole hydrochloride 具有抗感染和抗癌作用。
生物活性	Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride has anti-infection and anti-cancer effects.
性状	Solid
IC50 & Target[1][2]	Fungal
体外研究(In Vitro)	Neticonazole (10 μM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels. Neticonazole (0-10 μM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells. Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Tsuboi R, et al. Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group. Int J Dermatol. 1996 May;35(5):371-3. [2]. Datta A, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161.

溶解度数据	In Vitro: DMSO : 250 mg/mL (737.68 mM; Need ultrasonic)H₂O : ≥ 100 mg/mL (295.07 mM)

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation