α-Tocopherol phosphate disodium
目录号: PL14338 纯度: ≥98.0%
CAS No. :60934-46-5
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中文名称
α-Tocopherol phosphate disodium
中文别名
(+/-)-Alpha-生育酚磷酸二钠;(±)-Α-生育酚磷酸酯 二钠盐;(±)-α-生育酚磷酸酯
英文名称
α-Tocopherol phosphate disodium
英文别名
(+/-)-alpha-tocopherol phosphate disodium salt;sodium,[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-yl] dihydrogen phosphate;(+/-)-phenylglycine methyl este;(RS)-phenylglycine methyl ester hydrochloride;2-[carboxy-(2-phenoxy-acetylamino)-methyl]-5,5-dimethyl-thiazolidine-4-carboxylic acid;2-Amino-2,4-dimethyl-valeriansaeure;dl-2-methylleucine;DL-α-methylleucine;DL-α-tert-Butoxycarbonylamino-α-(2-thienyl)essigsaeure;DL-α-tocopherol phosphate disodium salt;methyl phenylglycinate hydrochloride;N-ME-DL-LEUCINE;usafdo-57;α-ME-DL-LEUCINE;α-methylleucine;α-Tocopherol phosphate disodium
Cas No.
60934-46-5
分子式
C29H49Na2O5P
分子量
554.65
包装储存
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
产品详情
α-Tocopherol phosphate (alpha-Tocopherol phosphate) 是一种抗氧化剂,可以保护长波 UVA1 诱导的细胞死亡,并清除 UVA1 诱导的活性氧 (ROS)。α-Tocopherol phosphate disodium 可抑制内皮祖细胞凋亡 (apoptosis),增加高糖/低氧条件下内皮祖细胞迁移能力,促进血管生成。
生物活性
α-Tocopherol phosphate (alpha-Tocopherol phosphate) disodium, a promising antioxidant, can protect against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium possesses therapeutic potential in the inhibition of apoptosis and increases the migratory capacity of endothelial progenitor cells under high-glucose/hypoxic conditions and promotes angiogenesis.
性状
Solid
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
ClinicalTrial
参考文献
[1]. Saleh MM, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11(1):22400.
[2]. Wu Z, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018 Apr;67(4):1263-1273.e1.
溶解度数据
In Vitro: DMSO : 4.55 mg/mL (8.20 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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