Sulfo-SMCC sodium|92921-24-9|-陌孚医药/Medlife

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Sulfo-SMCC sodium

目录号: PL14335 纯度: ≥97%

CAS No. :92921-24-9

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中文名称	Sulfo-SMCC sodium
中文别名	4-(N-马来酰亚胺甲基)环己烷-1-羧酸磺酸基琥珀酰亚胺酯钠盐;4-(N-马来酰亚胺基甲基)环己烷-1-羧酸-3-磺基琥珀酰亚胺酯;4-(N-马来酰亚胺基甲基)环己烷-1-羧酸3-硫代-N-琥珀酰亚胺酯钠盐;4-(N-马来酰亚胺基甲基)环己烷-1-羧酸-3-硫代-N-琥珀酰亚胺酯钠盐;Sulfo-SMCC 4-(N-马来酰亚胺甲基)环己烷-1-羧酸磺酸基琥珀酰亚胺酯钠盐;硫-SMCC, 4-(N-马来酰亚胺甲基)环己烷-1-羧酸磺酸基琥珀酰亚胺酯钠盐;硫代-SMCC 钠盐;4-(N-马来酰亚胺甲基)环己烷-1-羧酸 3-磺酸基-N-羟基琥珀酰亚胺酯钠盐;-琥珀酰亚胺酯钠盐;磺基琥珀酰亚胺基-4-(N-马来酰亚胺甲基)环己烷-1-羧酸酯;磺基-SMCC钠盐
英文名称	Sulfo-SMCC sodium
英文别名	Sodium 1-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarbonyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate;4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester;3-Sulfo-N-succinimidyl 4-(N-Maleimidomethyl)cyclohexane-1-carboxylate Sodium Salt;3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt;4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt;sodium,1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate;Sulfo-N-Succinimidyl;SULFO-N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANE-1 -CARBOXYLATE , SODIUM SALT;Sulfo-SMCC;Sulfo-SMCC (sodium);Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt;Sulfo-SMCC Sodium Salt;4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-Cyclohexanecarboxylic acid 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester sodium salt (1:1);Sulfo-SMCC sodium;Sulfo-SMCC Crosslinker;Sulfo-trans-SMCC;Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt;C16H17N2NaO9S;VUFNRPJNRFOTGK-UHFFFAOYSA-M;Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxy;3-Pyrrolidinesulfonic acid, 1-[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]oxy]-2,5-dioxo-, sodium salt (9CI);Sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate
Cas No.	92921-24-9
分子式	C₁₆H₁₈N₂NaO₉S
分子量	437.38
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	Sulfo-SMCC sodium 是一种常用的异双官能交联剂，是不可降解的 ADC linker，其带有N-羟基琥珀酰亚胺 (NHS) 酯和马来酰亚胺基团，分别与伯胺和巯基反应。
生物活性	Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
性状	Solid
IC50 & Target[1][2]	Non-cleavable
体外研究(In Vitro)	The crosslinker Sulfo-SMCC consists of a maleimide and an N-hydroxysuccinimide ester group to bind to sulfhydryl groups and primary amines, respectively. Sulfo-SMCC inhibits the end-to-end annealing of stabilized Microtubules (MTs). MTs are treated with 250 μM Sulfo-SMCC, and imaged after incubation for 0 h, 6 h, and 24 h. MTs treated with Sulfo-SMCC shows a constant mean length, independent of the incubation time. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Prabhune M, et al. Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. PLoS One. 2016 Aug 25;11(8):e0161623.

溶解度数据	In Vitro: DMSO : 125 mg/mL (286.45 mM; Need ultrasonic)H₂O : 5 mg/mL (11.46 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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