1-Dodecylimidazole|4303-67-7|(N-Dodecylimidazole)-陌孚医药/Medlife

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1-Dodecylimidazole (Synonyms: N-Dodecylimidazole)

目录号: PL14334 纯度: ≥99%

CAS No. :4303-67-7

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中文名称	1-Dodecylimidazole
中文别名	1-十二烷基咪唑;1-十二基咪唑;N-十二烷基咪唑;1-十二咪唑;1-十二烷基-1H-咪唑
英文名称	1-Dodecylimidazole
英文别名	1-Dodecyl-1H-imidazole;1-Dodecylimidazole;Imidazole, 1-dodecyl-;N-Dodecylimidazole;1H-Imidazole,1-dodecyl;1-Laurylimidazole;1-n-dodecanylimidazole;dodecylimidazole;EINECS 224-314-4;Imidazole,1-dodecyl;N-Laurylimidazole;1-dodecyl-imidazol;1-dodecyl-1h-imidazol;NSC 307267;JMTFLSQHQSFNTE-UHFFFAOYSA-N;1-Dodecylimidazole >98%;C15H28N2;Q27286867;1H-Imidazole, 1-dodecyl-;BRN 0609993;DS-6023;J-640443;DTXSID9063403;4303-67-7;FT-0607714;CHEMBL38032;1-dodeclimidazole;5-Ethyl thiophene -2-carboxaldehyde;SY029730;NSC307267;N-Dodecyl Imidazole;EC 224-314-4;AMY6319;CS-0149146;5-23-04-00264 (Beilstein Handbook Reference);1H -Imidazole, 1-dodecyl-;UNII-Q11NXV80S7;J-650001;MFCD00278859;AC1319;NSC-307267;J-800104;SCHEMBL284539;AKOS009159356;LS-78547;A872769;HY-138540;Q11NXV80S7;1-dodecyl-1h-imidazole;1-dodecylimidazole;1-laurylimidazole
Cas No.	4303-67-7
分子式	C₁₅H₂₈N₂
分子量	236.40
包装储存	Pure form -20°C 3 years；4°C 2 years

产品详情	1-Dodecylimidazole (N-Dodecylimidazole) 是一种溶酶体活性洗涤剂和细胞毒性剂。1-Dodecylimidazole 通过其在溶酶体中的酸依赖性积累、溶酶体膜的破坏和半胱氨酸蛋白酶释放到细胞质中而导致细胞死亡。1-Dodecylimidazole 具有降胆固醇和广谱抗真菌活性。
生物活性	1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.
性状	Liquid
体外研究(In Vitro)	N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase. 1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Pure form -20°C 3 years；4°C 2 years
参考文献	[1]. Wilson PD, et al. A relationship between multidrug resistance and growth-state dependent cytotoxicity of the lysosomotropic detergent N-dodecylimidazole. Biochem Biophys Res Commun. 1991;176(3):1377-1382. [2]. Atkin SD, et al. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent. Biochem J. 1972;130(1):153-157.

溶解度数据	In Vitro: DMSO : 100 mg/mL (423.01 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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