(±)-α-Tocopherol nicotinate|51898-34-1|(Vitamin E Nicotinate)-陌孚医药/Medlife

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(±)-α-Tocopherol nicotinate (Synonyms: Vitamin E Nicotinate)

目录号: PL14320

CAS No. :51898-34-1

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中文名称	(±)-α-Tocopherol nicotinate
中文别名	生育酚烟酸酯;维 E 烟酸酯;[2R(4R,8R)](±)-3-吡啶羧酸-3,4-二氢化-2,5,7,8-四甲基-2-[4,8,12-三甲基十三(烷)基]-2H-1-苯并吡喃-6-基酯（±）-α-烟酸生育酚维E 烟酸酯生育酚烟酸酯;(±)-α-生育酚烟酸酯;(±)-α-生育酚酯;（±）-α-烟酸生育酚;alpha-维生素E烟酸酯;水溶性维生素E烟酸酯;维生素E烟酸酯;维生素E烟酸酯、;维生素E烟酸酯标准品(JP);生育酚烟酸酯, 维E 烟酸酯,[2R(4R,8R)](±)-3-吡啶羧酸-3,4-二氢化-2,5,7,8-四甲基-2-[4,8,12-三甲基十三(烷)基]-2H-1-苯并吡喃-6-基酯
英文名称	(±)-α-Tocopherol nicotinate
英文别名	(+/-)-A-tocopherol nicotinate;Tocopherol Nicotinate;DL-alpha-Tocopherol Nicotinate;[2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)CHROMAN-6-YL] PYRIDINE-3-CARBOXYLATEALPHA-TOCOPHERYL NICOTINATEVITAMIN E NICOTINATE(+/-)-a-tocopherolnicotinate3,4-dihydro-2,5,7,8-tetramehyl-2(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ylester,[2R(4R,8R)]3-Pyridnecarboxyicacidvitaminenicotinate,tocopherylnicotinate3,4-dihydro-2,5,7,8-tetramehyl- 2(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester, [2R(4R,8R)]3-Pyridnecarboxyic acid[;(±)-α-Tocopherol nicotinate;Vitamin E Nicotinate;WATER SOLUBLE VITAMIN E NICOTINATE;[2R(4R,8R*)]-(+/-)-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl nicotinate;Vitamin E nicotinate
Cas No.	51898-34-1
分子式	C₃₅H₅₃NO₃
分子量	535.80
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	(±)-α-Tocopherol nicotinate，维生素 E-烟酸酯，是一种具有口服活性的脂溶性抗氧化剂，能够防止细胞膜脂质过氧化。(±)-α-Tocopherol nicotinate 在血液中可水解为 α -生育酚和烟酸，可用于相关血管疾病的研究。
生物活性	(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases.
性状	Solid
体外研究(In Vitro)	(±)-α-Tocopherol nicotinate can help slow the progression of microangiopathy in type 2 diabetics by reducing lipid peroxidation stress in the red blood cell membrane, improving blood rheology and red blood cell deformability. (±)-α-Tocopherol nicotinate (Vitamin E) (2 μg/mL, 24 h) increases the proportion of CD4+CD8-T cells in thymocytes by pretreating the thymic epithelial cell line IT45-R1 and then incubating it with immature T cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	(±)-α-Tocopherol nicotinate (Vitamin E) (in animal feedings, 50 mg/kg or 585 mg/kg, 7 weeks) significantly increases the proportion of CD4+CD8- T cells and the expression of ICAM-1 in thymic epithelial cells (TECs) isolated of male Fisher rats at high dose concentrations of 585 mg/kg compared to low dose treatment of 50 mg/kg. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. T W Chung, et al. Reducing lipid peroxidation stress of erythrocyte membrane by alpha-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabet Med. 1998 May;15(5):380-5. [2]. Satoru Moriguchi, et al.Vitamin E enhances T cell differentiation through increased epithelial cell function in rat thymus,Nutrition Research,Volume 17, Issue 5,1997,Pages 873-883.

溶解度数据	In Vitro: DMSO : 10 mg/mL (18.66 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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