琥珀酸维生素E;天然维生素E琥珀酸酯;[2R-[2R*(4R*,8R*)]][3,4-二氢-2,5,7,8-四甲基-2-(4,8,12-三甲基十三烷基)-2H-1-苯并吡喃-6-基]琥珀酸单酯;生育酚琥珀酸酯;DL-α-生育酚琥珀酸酯;维生素E琥珀酸酯;ALPHA生育酚琥珀酸酯;D-alpha-生育酚琥珀酸酯;D-α-生育酚琥珀酸盐;D-alpha-Tocopherol Succinate D-α-生育酚琥珀酸盐;D-a-维生素E琥珀酸酯;DL-α-生育酚琥珀酸酯,分析标准品;D-α-生育酚琥珀酸酯;天然维生素E-D-Α生育酚琥珀酸酯;维生素E琥珀酸酯标准品(JP);十八烷基三甲氧基硅烷;维生素E;维生素E琥珀酸盐;维他命E琥珀酸盐;维生素E琥珀酸酯 D-α-琥珀酸生育酚;维生素 E 琥珀酸酯;维生素 E 琥珀酸酯
D-α-Tocopherol Succinate (Vitamin E succinate) 是一种抗氧化生育酚,是维生素 E 的一种盐形式。D-α-Tocopherol Succinat 抑制 Cisplatin (HY-17394) 引起的毒性。D-α-Tocopherol Succinate 可用于癌症的研究。
生物活性
D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.
性状
Solid
体外研究(In Vitro)
D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells.D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity.D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Cytotoxicity Assay
体内研究(In Vivo)
D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor. has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;In solvent -80°C 6 months
参考文献
[1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14.[2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562.
溶解度数据
In Vitro: DMSO : 250 mg/mL (471.00 mM; Need ultrasonic)配制储备液