D-α-Tocopherol Succinate
目录号: PL14323 纯度: ≥98.0%
CAS No. :4345-03-3
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中文名称
D-α-Tocopherol Succinate
中文别名
琥珀酸维生素E;天然维生素E琥珀酸酯;[2R-[2R*(4R*,8R*)]][3,4-二氢-2,5,7,8-四甲基-2-(4,8,12-三甲基十三烷基)-2H-1-苯并吡喃-6-基]琥珀酸单酯;生育酚琥珀酸酯;DL-α-生育酚琥珀酸酯;维生素E琥珀酸酯;ALPHA生育酚琥珀酸酯;D-alpha-生育酚琥珀酸酯;D-α-生育酚琥珀酸盐;D-alpha-Tocopherol Succinate D-α-生育酚琥珀酸盐;D-a-维生素E琥珀酸酯;DL-α-生育酚琥珀酸酯,分析标准品;D-α-生育酚琥珀酸酯;天然维生素E-D-Α生育酚琥珀酸酯;维生素E琥珀酸酯标准品(JP);十八烷基三甲氧基硅烷;维生素E;维生素E琥珀酸盐;维他命E琥珀酸盐;维生素E琥珀酸酯 D-α-琥珀酸生育酚;维生素 E 琥珀酸酯;维生素 E 琥珀酸酯
英文名称
D-α-Tocopherol Succinate
英文别名
vitamin E succinate;(+)-A-tocopherol acid succinate from*natural A-to;alpha-tocopheryl hydrogen succinate;DL-alpha-Tocopherol succinate;D-alpha-Tocopherol Succinate;D-a-Tocopherol acid Succinate;(+)-ALPHA-TOCOPHEROL ACID SUCCINATE;D-α-Tocopherol succinate;VITAMIN E SUCCINATE(TOCOPHEROL SUCCINATE)(P) PrintBack;VITAMIN E SUCCINATE(TOCOPHEROL SUCCINATE)(RG) PrintBack;α-Tocopheryl Succinate;d-alpha-Tocopherol succinate(E);TriMethoxy(octadecyl)silane;alpha-Tocopheryl succinate;tocopherol succinate;alpha-tocopherol succinate;D-ALPHA-TOCOPHERYL SUCCINATE;d-;A-tocopheryl succinate;Covitol 1210;d-alpha-Tocopherol acid succinate;LU4B53JYVE;alpha-Tocopherol hemisuccinate;alpha-Tocopheryl acid succinate;alpha-Tocopheryl succinate, D-;D-alpha tocopheryl acid succinate;d-alpha-Tocopheryl acid succinate;Tocopherol acid succinate, alpha-;IELOKBJP;Vitamin E hemisuccinate;alpha-Vitamin E succinate;(+)-alpha-Tocopheryl succinate;Tocopherol ;D- alpha Tocopheryl Acid Succinate
Cas No.
4345-03-3
分子式
C33H54O5
分子量
530.78
包装储存
Powder -20°C 3 years;In solvent -80°C 6 months
产品详情
D-α-Tocopherol Succinate (Vitamin E succinate) 是一种抗氧化生育酚,是维生素 E 的一种盐形式。D-α-Tocopherol Succinat 抑制 Cisplatin (HY-17394) 引起的毒性。D-α-Tocopherol Succinate 可用于癌症的研究。
生物活性
D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.
性状
Solid
体外研究(In Vitro)
D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells.
D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity.
D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Cytotoxicity Assay
体内研究(In Vivo)
D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;In solvent -80°C 6 months
参考文献
[1]. Kim SK, et al. The effects of the antioxidant α-tocopherol succinate on cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol. 2016 Jul;86:9-14.
[2]. Kang TH, et al. Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects. PLoS One. 2014 Jul 29;9(7):e103562.
溶解度数据
In Vitro: DMSO : 250 mg/mL (471.00 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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