Fenoterol hydrobromide|1944-12-3|(非诺特罗氢溴酸盐; Th-1165a; Phenoterol hydrobromide)-陌孚医药/Medlife

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Fenoterol hydrobromide (Synonyms: 非诺特罗氢溴酸盐; Th-1165a; Phenoterol hydrobromide)

目录号: PL14307 纯度: ≥99%

CAS No. :1944-12-3

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中文名称	Fenoterol hydrobromide
中文别名	非诺特罗氢溴酸;氢溴酸菲诺特罗标准溶液;氢溴酸菲诺特罗;2,4-二氯呋喃[2,3-D]嘧啶;非诺特罗;非诺特罗标准品;非诺特罗氢溴酸盐;氢溴酸非诺特罗;氢溴酸非诺特罗标准品;氢溴酸芬忒醇英文名称：1-(3,5-dihydroxy-phenyl)-2-((1-(4-hydroxybenzyl)ethyl)amino)-ethanolhydrobro;甲醇中菲诺特罗;氢溴酸芬忒醇;菲诺特洛氢溴酸盐;甲醇中菲诺特罗溶液标准物质;氢溴酸非诺特罗非诺特罗氢溴酸盐;5-[1-羟基-2-[[2-(4-羟基苯基)-1-甲基乙基]氨基]乙基]-1,3-苯二醇;酚丙喘宁芬忒醇;氢溴酸非诺特罗非诺特罗氢溴酸盐;氢溴酸非诺特罗/酚丙喘宁芬忒醇
英文名称	Fenoterol hydrobromide
英文别名	1,3-Benzenediol,5-[1-hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-, hydrobromide(1:1);Fenoterol solution;1,3-Benzenediol,5-[1-hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-, hydrobromide...;FENOTEROL HYDROBROMIDE;Fenoterol;5-[1-hydroxy-2-[1-(4-hydroxyphenyl)propan-2-ylamino]ethyl]benzene-1,3-diol,hydrobromide;Fenoterol bromide;fenoterol*HBr;fenoterole hydrobromide;Phenoterol hydrobromide;Th-1165a;UNII-RLI45Z99RB;2-(3,5-Dihydroxyphenyl)-2-hydroxy-2′-(4-hydroxyphenyl)-1′-methyldiethylamine hydrobromide;berotec;berotec hydrobromide;partusisten;5-[1-Hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-1,3-benzenediol hydrobromide;Airum;Emitex;Ugacor;th1165a;Siobetec;Dosberotec;FENOTEROL HBR;fenoterolbromide;fenoterol bromide;fenoterol hydrobromide;phenoterol hydrobromide;Fenoterol hydrobromide
Cas No.	1944-12-3
分子式	C₁₇H₂₁NO₄^.HBr
分子量	384.26
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Fenoterol hydrobromide (Th-1165a) 是拟交感神经剂，是一种选择性的，具有口服活性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂。Fenoterol hydrobromide 是一种有效的支气管扩张剂，可用于与哮喘，支气管炎和其他阻塞性气道疾病相关的支气管痉挛的研究。

生物活性

Fenoterol hydrobromide (Th-1165a), a sympathomimetic agent, is a selective and orally active β2-adrenoceptor agonist. Fenoterol hydrobromide is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research.

性状

Solid

体外研究(In Vitro)

Fenoterol (1 μM; pre-incubated 30 minutes) treatment reduces AICAR-induced AMPK activation, NF-κB activation and TNF-α release, and also significantly downregulates the elevated phosphorylation levels of AMPK.
Fenoterol inhibits lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells.
Fenoterol is also a potent exosome biogenesis and/or secretion activator in PC cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Fenoterol (0.7 mg/kg; intraperitoneal injection; twice a day; for 3 weeks) treatment suppresses mechanical allodynia during chronic treatment. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. R C Heel, et al. Fenoterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Drugs. 1978 Jan;15(1):3-32.
[2]. Wei Wang, et al. Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells. Biomed Pharmacother. 2016 Dec;84:185-190.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (260.24 mM)H₂O : 25 mg/mL (65.06 mM; Need ultrasonic)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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