Terbutaline sulfate|23031-32-5|(硫酸特布他林; Terbutaline hemisulfate)-陌孚医药/Medlife

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Terbutaline sulfate (Synonyms: 硫酸特布他林; Terbutaline hemisulfate)

目录号: PL14306 纯度: ≥99%

CAS No. :23031-32-5

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中文名称	Terbutaline sulfate
中文别名	硫酸特布他林;硫酸叔丁宁按;特布他林半硫酸盐;2-叔丁氨基-1-(3,5-二羟基苯基)乙醇硫酸盐 (2:1);特布他林硫酸盐;硫酸叔丁喘宁;特布它林硫酸盐;叔丁喘宁;特布它林甲醇溶液标准物质;甲醇中特布它林溶液标准物质;硫酸特布他林 EP标准品;硫酸特布他林 USP标准品;硫酸特布他林标准品;硫酸特布他林原药;特布他林半硫酸盐标准品;治疗支气管哮喘
英文名称	Terbutaline sulfate
英文别名	terbutaline hemisulfate;1-(3,5-dihydroxyphenyl)-2-tert-butylaminoethanolsulphate;3-benzenediol,5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-sulfate(2;alpha-((tert-butylamino)methyl)-3,5-dihydroxybenzylalcoholsulfate(2:1)(sa;alpha-((tert-butylamino)methyl)-3,5-dihydroxy-benzylalcohosulfate(2:1);bricanyl;Bricanyl[R];2-tert-Butylamino-1-(3,5-dihydroxyphenyl)ethanol, Brethaire, Brethine, Butaliret, Monovent, Terbasmin, Terbul;TERBASMIN;Terbutaline Hemisulfate Salt;Terbutaline solution;5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol,sulfuric acid;Terbutaline Hemisulf;TERBUTALINE SULFATE;(+/-)-terbutaline hemisulphate;1-(3,5-dihydroxyphenyl)-2-(t-butylam;2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol;2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol Terbutaline hemisulfate salt;Brethine (TN);rac-terbutaline sulfate;5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt;2-tert-Butylamino-1-(3,5-dihydroxyphenyl)ethanol hemisulfate;DSSTox_CID_25437;DSSTox_RID_80878;DSSTox_GSID_45437;2-t-Butylamino-1-[3,5-dihydroxyphenyl]ethanol;5-(2-(tert-butylamino)-1-hydroxyethyl)benzene-1,3-diol hemisulfate;KWD 2019;5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol;sulfuric acid;terbutaline-sulfate;Prestwick_598;Terbutaline(sulfate);Terbutaline (sulfate);5-[2-(tert-butylamino)-;Terbutaline hemisulfate;Terbutaline sulfate
Cas No.	23031-32-5
分子式	C₂₄H₄₀N₂O₁₀S
分子量	548.65
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Terbutaline sulfate 是一种具有口服活性的 β₂-肾上腺素能受体激动剂，是班布特罗的活性代谢产物。Terbutaline sulfate 可用于哮喘研究。

生物活性

Terbutaline sulfate is an orally active β 2 -adrenergic receptor agonist and an active metabolite of bambuterol. Terbutaline sulfate can be used in asthma symptom research.

性状

Solid

IC50 & Target[1][2]

β adrenergic receptor

体外研究(In Vitro)

Terbutaline sulfate (0-10 μM, 1 hour) enhances MKP-1 expression in activated mouse macrophages. has not independently confirmed the accuracy of these methods. They are for reference only.RT-PCR

体内研究(In Vivo)

Terbutaline sulfate (intraperitoneal injection; 0.5 mg/kg; twice a day; 20 days) treatment can improve the allodynia in ob/ob mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Mohamed Ismail NA, et al. Nifedipine versus terbutaline for tocolysis in external cephalic version. Int J Gynaecol Obstet. 2008 Sep;102(3):263-6.
[2]. Joana A Loureiro, et al. The interaction of a β2 adrenoceptor agonist drug with biomimetic cell membrane models: The case of terbutaline sulphate. Life Sci. 2021 Nov 15;285:119992.

溶解度数据	In Vitro: H₂O : 250 mg/mL (911.34 mM; Need ultrasonic)DMSO : 5 mg/mL (18.23 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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