Octopamine-d4 (hydrochloride)|1219803-62-9|-陌孚医药/Medlife

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Octopamine-d4 (hydrochloride)

目录号: PL14292

CAS No. :1219803-62-9

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中文名称	Octopamine-d4 (hydrochloride)
中文别名	(±)-p-章鱼胺-α,β,β-d3盐酸盐;2,3,3',4,4',5-六氯联苯;章胺盐酸-D3氘代
英文名称	Octopamine-d4 (hydrochloride)
英文别名	rac Octopamine-d3 Hydrochloride;4-(2-amino-1,2,2-trideuterio-1-hydroxyethyl)phenol,hydrochloride;rac Octopamine-d3 Hy;(+/-)-p-Octopamaine-d3 Hydrochloride;A-(Aminomethyl)-4-hydroxybenzenemethanol-d3 Hydrochloride;DL-Octopamine-d3 Hydrochloride;Epirenor-d3;Norfen-d3;Octopamine-d3 Hydrochloride
Cas No.	1219803-62-9
分子式	C₈H₁₁NO₂^.HCl
分子量	189.64
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Octopamine-d₄ (hydrochloride) 是 Octopamine hydrochloride 的氘代物。Octopamine ((±)-p-Octopamine) hydrochloride 是一种与去甲肾上腺素结构相关的生物单胺类物质，在无脊椎动物中起着神经激素、神经调节剂和神经递质的作用。Octopamine hydrochloride 对转染人 alpha2-肾上腺素受体(ARs) 的中国仓鼠卵巢细胞 α2-ARs 有刺激作用。Octopamine hydrochloride 增加糖原分解、糖酵解、摄氧量、糖异生和门脉灌注压。
生物活性	Octopamine-d 4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure[1][2][3].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Farooqui T. Octopamine-mediated neuromodulation of insect senses. Neurochem Res. 2007;32(9):1511-1529. [3]. Roeder T. Octopamine in invertebrates. Prog Neurobiol. 1999;59(5)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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