Sertindole|106516-24-9|(舍吲哚; Lu 23-174)-陌孚医药/Medlife

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Sertindole (Synonyms: 舍吲哚; Lu 23-174)

目录号: PL14286 纯度: ≥99%

CAS No. :106516-24-9

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中文名称	Sertindole
中文别名	舍吲哚;(R)-1-(4-氟苯基)乙醇;1-[2-[4-[5-氯-1-(4-氟苯基)-1H-吲哚-3-基]-1-哌啶基]乙基]-2-咪唑二酮;Sertindole 舍吲哚;去甲脱氧氯酸;1-[2-[4-[5-氯-1-(4-氟苯基)-1H-吲哚-3-基]-1-哌啶基]乙基]-2-咪唑啉酮;1-[2-[4-[5-氯-1-(4-氟苯基)-1H-吲哚-3-基]-1-哌啶基]乙基]-2-咪唑烷酮
英文名称	Sertindole
英文别名	1-(2-(4-(5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl)piperidin-1-yl)ethyl)imidazolidin-2-one;Sertindole;2-Imidazolidinone, 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-;Lu 23-174;1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone;1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one;Zerdol;SerLect;Serdolect;Sertindol;Sertindolum;Sertindolum [INN-Latin];Sertindol [INN-Spanish];GVV4Z879SP;1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one;GZKLJWGUPQBVJQ-UHFFFAOYSA-N;1-(2-(4-(5-Chloro-1-(4-fluorophenyl)-1H-indole-3-yl)-1-piperidinyl)ethyl)-2-imidazolidinone;1-(2-(4-(5-Chloro-1-(p-fluorophenyl)indol-3-yl)piperidino)ethyl)-2-imidazolidinone;NCGC00181782;1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
Cas No.	106516-24-9
分子式	C₂₄H₂₆ClFN₄O
分子量	440.94
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Sertindole (Lu 23-174) 是一种具有口服活性的 5-HT_2A、5-HT_2C、dopamine D₂、和 αl-adrenergic 受体拮抗剂。Sertindole 表现出对多种癌症细胞的抗增殖活性并可用于抗精神病的研究。

生物活性

Sertindole (Lu 23-174) is an orally active 5-HT 2A , 5-HT 2C , dopamine D 2 , and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells.

性状

Solid

IC50 & Target[1][2]

5-HT2A Receptor 5-HT2C Receptor

体外研究(In Vitro)

Sertindole (0-100 μM; 48 h) attenuates proliferation of breast cancer cells.
Sertindole (0.8-27.6 μM; 48 h) inhibits proliferation toward many cancers in vitro.
Sertindole (5?μΜ and 10 μΜ; 24 h) attenuates migration of breast cancer cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay

体内研究(In Vivo)

Sertindole (oral gavage; 10?mg/kg; once daily; 12 d) shows anti-tumor activity in vivo. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Immune-deficient Balb/c mice implanted MDA-MB-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. David Murdoch, et al. Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20(3):233-55.
[2]. Wei Zhang, et al. Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Sci Rep. 2018 Oct 25;8(1):15753.

溶解度数据	In Vitro: DMSO : 25 mg/mL (56.70 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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