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Amezinium methylsulfate

(Synonyms: Amezinium metilsulfate; Lu-1631)

目录号: PL14294 纯度: ≥99%

Amezinium metilsulfate刺激 alpha 和beta-1受体, 抑制去甲肾上腺素和酪胺吸收。

CAS No. :30578-37-1

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中文名称	Amezinium methylsulfate
中文别名	甲磺美嗪;6-甲氧基-1-苯基哒嗪-1-鎓-4-胺甲磺酸盐;Amezinium Methyl Sulfate 甲磺美嗪;4-氨基-6-甲氧基-1-苯基哒嗪甲磺酸盐
英文名称	Amezinium methylsulfate
英文别名	Amezinium methylsulfate;6-Methoxy-1-phenylpyridazin-1-ium-4-amine methylsulfate;AMEINIUM METHYL SULFATE;Amezinium Metilsulfate;4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfate;amexinium methyl sulfate;Amezinii metilsulfas [INN-Latin];Amezinio metilsulfato [Spanish];Ameziniummetilsulfat [German];EINECS 250-248-0;Lu-1631;Metilsulfate d'amezinium [INN-French];Regulton;Supratonin;4-Amino-6-methoxy-1-phenylpyridazinium Methyl Sulfate
Cas No.	30578-37-1
分子式	C₁₁H₁₂N₃O^.CH₃O₄S
分子量	313.33
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Amezinium metilsulfate刺激 alpha 和beta-1受体, 抑制去甲肾上腺素和酪胺吸收。

产品详情	Amezinium metilsulfate刺激 alpha 和beta-1受体, 抑制去甲肾上腺素和酪胺吸收。
生物活性	Amezinium metilsulfate has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition ofnoradrenaline and tyramine uptake. Target: alpha and beta-1 receptors Amezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. Cardiovascular effects of the new sympathomimetic Amezinium metilsulphate are investigated in 25 patients compared with a control group (n = 25). During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. from starting-point. A significant recovery of blood pressure (epidural anaesthesia: syst 21%, diast 9%; spinal anaesthesia: syst 13%, diast 6.6%) and a decrease in heart rate (6.8% resp. 4,5%) are thought due to peripheral vasoconstriction. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia.
性状	Solid
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Schaps D, et al. Therapeutic use of amezinium methylsulfate--a new, long acting, sympathomimetic--in paraspinal conduction anesthesia. Anasth Intensivther Notfallmed. 1984 Oct;19(5):235-9.

溶解度数据	In Vitro: H₂O : 50 mg/mL (159.58 mM; Need ultrasonic)DMSO : ≥ 34 mg/mL (108.51 mM)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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