JP1302 dihydrochloride|1259314-65-2|-陌孚医药/Medlife

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JP1302 dihydrochloride

目录号: PL14279 纯度: ≥99%

CAS No. :1259314-65-2

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中文名称	JP1302 dihydrochloride
中文别名	N-(4-(4-甲基哌嗪-1-基)苯基)吖啶-9-胺二盐酸盐
英文名称	JP1302 dihydrochloride
英文别名	JP 1302 dihydrochloride;JP 1302 2HCl;JP1302 dihydrochloride
Cas No.	1259314-65-2
分子式	C₂₄H₂₆Cl₂N₄
分子量	441.40
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	JP1302 dihydrochloride 是选择性的、高亲和力的 α_2C 肾上腺受体 (α_2C-adrenoceptor) 的拮抗剂，其对人类 α_2C 受体的 K_b 值为 16 nM，K_i 为 28 nM。JP1302 dihydrochloride 具有抗抑郁和类抗精神病作用。JP1302 dihydrochloride 可用于神经精神障碍和肾功能障碍的研究。
生物活性	JP1302 dihydrochloride is a potent, selective, high affinity antagonist of the α 2C -adrenoceptor, with a K b of 16 nM and a K i of 28 nM for the human α 2C -receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research.
性状	Solid
IC50 & Target[1][2]	human α2C-adrenoceptor 28±2 nM (Ki) human α2B-adrenoceptor
体外研究(In Vitro)	JP1302 shows about 100-fold higher affinity than for α2A or α2B. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30?μmol/kg of the antidepressant Desipramine (HY-B1272A). JP1302 (5 μmol/kg, once) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine and similar results are found in Wistar rats. JP1302 (3 mg/kg, IV, once) significantly ameliorates renal dysfunction. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Tricklebank MD, et al. JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain. Br J Pharmacol. 2007 Feb;150(4):381-2. [2]. Sallinen J, et al. Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150(4):391-402.

溶解度数据	In Vitro: H₂O : 12.5 mg/mL (28.32 mM; Need ultrasonic)DMSO : 5 mg/mL (11.33 mM; ultrasonic and adjust pH to 5 with NaOH)配制储备液

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