Dapiprazole hydrochloride|72822-13-0|(盐酸达哌唑)-陌孚医药/Medlife

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Dapiprazole hydrochloride (Synonyms: 盐酸达哌唑)

目录号: PL14264 纯度: ≥99%

CAS No. :72822-13-0

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中文名称	Dapiprazole hydrochloride
中文别名	Dapiprazole HCI 盐酸达派唑;盐酸达哌拉唑;盐酸达哌唑
英文名称	Dapiprazole hydrochloride
英文别名	1,2,4-Triazolo[4,3-a]pyridine,5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-,hydrochloride (1:1);Dapiprazole Hydrochloride;1,2,4-Triazolo[4,3-a]pyridine,5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]...;Dapiprazole (hydrochloride);AF 2139;AF-2139;Dapiprazole HCl;Dapiprazole hydrochloride (USAN);DSSTox_CID_28595;DSSTox_GSID_48669;DSSTox_RID_82866;Rev-Eyes;5,6,7,8-Tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine hydrochloride;Dapiprazole hydrochloride
Cas No.	72822-13-0
分子式	C₁₉H₂₇N₅^.HCl
分子量	361.91
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Dapiprazole hydrochloride 是一种有效的、选择性的、具有口服活性的 α -1 肾上腺素受体 (alpha-1 adrenoceptor) 拮抗剂。Dapiprazole hydrochloride 抑制阿片类戒断症状。Dapiprazole hydrochloride 也可用作逆转瞳孔扩大的滴眼液。
生物活性	Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis.
性状	Solid
IC50 & Target[1][2]	α1-adrenergic receptor
体内研究(In Vivo)	Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Valeri P, et al. Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Drug Alcohol Depend. 1989 Jan;23(1):73-7. [2]. Allinson RW, et al. Reversal of mydriasis by dapiprazole. Ann Ophthalmol. 1990 Apr;22(4):131-3, 138. [3]. Hou RH, et al. Arousal and

溶解度数据	In Vitro: H₂O : 50 mg/mL (138.16 mM; Need ultrasonic)DMSO : 12.5 mg/mL (34.54 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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