Monastrol是具有高效性和细胞渗透性的有丝分裂驱动蛋白 Eg5 的抑制剂，IC₅₀ 值为 14 μM。

Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC 50 value of 14 μM.

Solid

Eg5 14 μM (IC50)

Monastrol is a small, cell-permeable molecule that arrests cells in mitosis by specifically inhibiting Eg5, a member of the Kinesin-5 family. Monastrol treatment of dividing cells results in spindle collapse and cell cycle arrest with a monoastral spindle, which is similar to the phenotype observed when Eg5 is inhibited by anti-Eg5 antibodies. Monastrol is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cell lines. Monastrol treatment can decrease cell viability in MCF-7 tumor cells. Real-time cell growth kinetic analysis showed a decrease in the proliferation of MCF-7 cells exposed to monastrol. has not independently confirmed the accuracy of these methods. They are for reference only.

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Powder -20°C 3 years；4°C 2 years

[1]. Cochran JC, et al. Monastrol inhibition of the mitotic kinesin Eg5. J BiolChem. 2005 Apr 1;280(13):12658-67.
[2]. Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286(5441):971-4.
[3]. Marques LA, et al. Antiproliferative activi

In Vitro: DMSO : ≥ 33 mg/mL (112.88 mM)配制储备液