Ethoxylated hydrogenated castor oil|61788-85-0|(PEG-40 hydrogenated castor oil; Macrogolglycerol hydroxystearate; Castor oil, hydrogenated, polyethoxylated)-陌孚医药/Medlife

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Ethoxylated hydrogenated castor oil (Synonyms: PEG-40 hydrogenated castor oil; Macrogolglycerol hydroxystearate; Castor oil, hydrogenated, polyethoxylated)

目录号: PL14074

CAS No. :61788-85-0

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中文名称	Ethoxylated hydrogenated castor oil
中文别名	氢化蓖麻油;聚氧乙烯氢化蓖麻油;乳化剂HEL;PEG-10 氢化蓖麻油;PEG-100 氢化蓖麻油;PEG-20 氢化蓖麻油;PEG-40 氢化蓖麻油;PEG-45 氢化蓖麻油;PEG-50 氢化蓖麻油;PEG-60 氢化蓖麻油;PEG-7 氢化蓖麻油;POE(25)氢化蓖麻油;高效增溶剂Gelfest CO40;聚氧乙烯(10)氢化蓖麻油;聚氧乙烯氢化蓖麻油 Cremophor 乳化剂HEL;聚氧乙烯氢化蓖麻油乳化剂HEL-20 Cremophor;聚氧乙烯氢化蓖麻油乳化剂HEL-40 Cremophor;聚氧乙烯氢化蓖麻油40;氢化蓖麻油聚氧乙烯醚;土耳其红油磺化蓖麻油纺织印染太古油磺化油;氢化蓖麻油聚氧乙烯醚,Cremophor RH40;聚氧乙烯氢化蓖麻油RH40
英文名称	Ethoxylated hydrogenated castor oil
英文别名	Ethoxylated hydrogenated castor oil;Castor oil, hydrogenated, ethoxylated;Polyoxyethylene hydrogenated castor oil;Hydrogenated Castor Oil Ethoxylate;peg-25;POE(16)hydrogenatedcastoroil;POE(25)hydrogenatedcastoroil;Polyoxyethylene(10) Hydrogenated Castor Oil;Emulsifier HEL;PEG-40 Hydrogenated Castor Oil;Polyethyleneglycol castor oil, hydrogenated;Aloperidin;Bioperidolo;Brotopon;Dozic;Einalon S;Eukystol;Haldol;haloperidol;halopéridol;Haloperidol D4;Haloperidol for peak identification;Haloperidol for system suitability;haloperidolum;Halosten;Keselan;Linton;Peluces;Serenace;Sigaperidol;Aloperidon;Apo-Haloperidol;Dozix;Haldol La;Halidol;Halol;Haloperido;Halopidol;Pekuces;Peridol;1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine;1-Butanone, 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-;4-(4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone;4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one;4-(4-(para-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone;4-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone;4-(4-Hydroxy-4'-chloro-4-phenylpiperidino)-4'-fluorobutyrophenone;4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone;4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone;4'-Fluoro-4-(4-hydroxy-4-p-chlorophenylpiperidino)butyrophenone;Aldo;Aloperidin;Bioperidolo;Brotopon;Dozic;Duraperidol;Einalon S;Haldol;Aloperidol;Aloperidolo;Butyrophenone, 4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-4'-fluoro-;Butyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidino)-;DB00502;Duraperidol;-fluorobutyrophenone;Fortunan;Galoperidol;Haldol®;Halojust;Halopal;HALOPERIDO-D4;Halopoidol;https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5613;Keselen;Mastic gum;Mixidol;Pernox;Picroside III;Picroside-III;Resin epoxy;Serenace®;SERENASE;Serenelfi;Sernas;Sernel;Ulcolind;Uliolind;Vesalium;γ-(4-(p-chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone;γ-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorbutyrophenone;γ-(4-(p-Chlorophenyl)-4-hydroxypiperidino)-p-fluorobutyrophenone;Kolliphor RH40
Cas No.	61788-85-0
分子式	C₂₁H₂₃ClFNO₂
分子量	375.86
包装储存	4°C, protect from light

产品详情

Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) 是聚乙二醇 (PEG) 与天然蓖麻油的混合物。Ethoxylated hydrogenated castor oil 可用于水包油 (o/w) 乳浊液的乳化和增溶。Ethoxylated hydrogenated castor oil 可以作为动物实验的助溶剂。

生物活性

Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o/w) emulsions. Ethoxylated hydrogenated castor oil can be used as a cosolvent in vivo.

性状

Oil

体内研究(In Vivo)

20% PEG-40 hydrogenated castor oil (10 μl) is applied to the left ear of the mouse, and the right ear served as a control. The mice are observed for development of erthyma for 6 days, no signs of irritation are observed in the mice.
PEG-40 hydrogenated castor oil (injection via the tail vein; 300, 900, and 2700 mg/kg; 4 weeks) is administared for short-term toxicity. At doses of 300 and 900 mg/kg PEG-40 Hydrogenated Castor Oi exhibits no systemic toxicity. However, at a dose of 2700 mg/kg, slight ataxia is observed and body weight is reduced significantly in the males and slightly in the females.
A toxicity study of blank nanoemulsion using PEG-40 hydrogenated castor oil as a surfactant is applied in order to load various active compounds for oral administration.
Nearly 20% of PEG-40 hydrogenated castor oil was used to emulsify the glyceryl monooleate (GMO) as an oil

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

ClinicalTrial

参考文献

[1]. PEG-40 HYDROGENATED CASTOR OIL
[2]. Heni Rachmawati, et al. The In Vitro-In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation. Sci Pharm. 2017 Mar 31;85(2):18. doi: 10.3390/scipharm85020018.
[3]. PEGylated Oils as Used in Cosmetics

溶解度数据	In Vitro: H₂O : ≥ 100 mg/mL

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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