VAF347 是一种细胞可渗透且高度亲和力的芳烃受体 (AhR) 激动剂，可诱导 AhR 信号传导。VAF347 抑制颗粒单核细胞 (GM 期) 前体中 CD14⁺CD11b⁺ 单核细胞的发育。VAF347 具有抗炎作用。

VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14CD11b monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects.

Solid

Aryl hydrocarbon receptor

VAF347 (0.01-20 μM; 48-72 hours; HL-60 cells) treatment enhances retinoic acid-induced cell cycle arrest.
VAF347 (20 μM; 48 hours; HL-60 cells) treatment augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of partners in the signalsome appear to be enhanced: Fgr interaction with c-Cbl, CD38, and with pS259c-Raf and AhR interaction with c-Cbl and Lyn.
VAF347 inhibits IL-4 GM-CSF induced IL-6 production in MM1 cells with an IC50 of ~5 nM. has not independently confirmed the accuracy of these methods. They are for reference only.

In wild-type mice, VAF347 treatment leads to a strong reduction of total serum IgE levels compared with vehicle-treated animals. IL-5 levels in the bronchoalveolar fluid are inhibited to a comparable degree. AhR-deficient mice are resistant to the VAF347s ability to block allergic lung inflammation in vivo. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Ibabao CN, et al. The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells. FEBS Open Bio. 2015 Apr 8;5:308-18.
[2]. B Paige Lawrence, et al. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound. Blood. 2008 Aug 15;112(4):1158-65.

In Vitro: DMSO : 31.25 mg/mL (89.35 mM; Need ultrasonic)配制储备液