Diprotin A|90614-48-5|(Ile-Pro-Ile)-陌孚医药/Medlife

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Diprotin A (Synonyms: Ile-Pro-Ile)

目录号: PL13891 纯度: ≥99%

CAS No. :90614-48-5

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中文名称	Diprotin A
中文别名	L-异亮氨酰-L-脯氨酰-L-异亮氨酸;抑二肽素A
英文名称	Diprotin A
英文别名	L-Isoleucine,L-isoleucyl-L-prolyl-;DiprotinA;H-Ile-Pro-Ile-OH;ILE-PRO-ILE;DIPEPTIDYLPEPTIDASE IV INHIBITOR I;H-ILE-PRO-ILE-OH H2O;ILE-PRO-ILE H2O;Ile-Pro-Ile-OH;L-Ile-L-Pro-L-Ile-OH;L-Isoleucyl-L-prolyl-L-isoleucine;Diprotin A;Ile-Pro-Ile;L-Isoleucine, N-(1-L-isoleucyl-L-prolyl)- (ZCI);L-Isoleucyl-L-prolyl-L-isoleucine (ACI);3: PN: JP2011182742 SEQID: 3 unclaimed protein
Cas No.	90614-48-5
分子式	C₁₇H₃₁N₃O₄
分子量	341.45
包装储存	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

产品详情	Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。
生物活性	Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
性状	Solid
IC50 & Target[1][2]	IC50: DPP-IV
体外研究(In Vitro)	Diprotin A (100?μM; 30?minutes after CXCR4-blocker or Src-inhibitor treatment) induces the phosphorylation of Src [Tyr 416] and VE-cadherin [Tyr731] in hECs in both normoxia and H/R conditions in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analy
体内研究(In Vivo)	Diprotin A (intraperitoneal injection; 70?μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye
参考文献	[1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.

溶解度数据	In Vitro: DMSO : 250 mg/mL (732.17 mM; Need ultrasonic)H₂O : ≥ 100 mg/mL (292.87 mM)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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