ZL0420|2230496-80-5|-陌孚医药/Medlife

您当前的位置：

ZL0420

目录号: PL13508 纯度: ≥98.0%

CAS No. :2230496-80-5

商品编号	规格	价格	会员价
PL13508-5mg	5mg	¥1483.64	请登录
PL13508-10mg	10mg	¥2349.09	请登录
PL13508-25mg	25mg	¥4698.18	请登录
PL13508-50mg	50mg	¥8530.91	请登录
PL13508-100mg	100mg	询价	询价
PL13508-200mg	200mg	询价	询价
PL13508-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1632.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	ZL0420
英文名称	ZL0420
英文别名	ZL0420;2(1H)-Quinolinone, 6-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-
Cas No.	2230496-80-5
分子式	C₁₆H₁₆N₄O₂
分子量	296.32
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	ZL0420 是有效且选择性的 BET 溴结构域 4 (BRD4) 抑制剂，对 BRD4 BD1和 BRD4 BD2 的 IC₅₀ 分别为 27 nM 和 32 nM。
生物活性	ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC 50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2.
性状	Solid
IC50 & Target[1][2]	IC50: 27 nM (BRD4 BD1), 32 nM (BRD4 BD2)
体外研究(In Vitro)	ZL0420 is well docked into the acetyl-lysine (KAc) binding pocket of BRD4, forming key interactions including the critical hydrogen bonds with Asn140 directly and Tyr97 indirectly via a H2O molecule. ZL0420 exhibits submicromolar potency of inhibiting the TLR3-dependent innate immune gene program, including ISG54, ISG56, IL-8, and Groβ genes in cultured human small airway epithelial cells (hSAECs) with IC50s of 0.49-0.86 μM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	ZL0420 demonstrates potent efficacy reducing airway inflammation in a mouse model with low toxicity. ZL0420 displays high efficacy and almost completely blocks the profound accumulation of neutrophils around the small and medium sized airways induced by poly(I:C) administration. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Liu Z, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461.

溶解度数据	In Vitro: DMSO : 125 mg/mL (421.84 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation