Basiliximab|179045-86-4|(CHI 621)-陌孚医药/Medlife

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Basiliximab (Synonyms: CHI 621)

目录号: PL13382 纯度: 95.0%

CAS No. :179045-86-4

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PL13382-50mg	50mg	询价	询价

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中文名称	Basiliximab
中文别名	巴利昔单抗
英文名称	Basiliximab
英文别名	basiliximab;Basiliximab [USAN];Immunoglobulin G 1 (human-mouse monoclonal CHI621 heavy chain anti-human interleukin 2 receptor), disulfide with human-mouse monoclonal CHI621 light chain, dimer;Immunoglobulin G1 (human-mouse monoclonal CHI621 heavy chain antihuman interleukin 2 receptor), disulfide with human-mouse monoclonal CHI621 light chain, dimer;Immunoglobulin G1, anti-(human interleukin 2 receptor) (human-mouse monoclonal CHI621 gamma1-chain), disulfide with human-mouse monoclonal CHI621 light chain, dimer;SDZ-CHI-621;Simulect;UNII-9927MT646M;BAILIXIMAB;Immunoglobulin G1, anti-(human interleukin 2 receptor) (human-mouse monoclonal CHI6;CHI 621;from USAN List 422;SDZ-CHI 621;Basiliximab
Cas No.	179045-86-4
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Basiliximab (CHI 621) 是一种重组嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 抗体。Basiliximab 可用于肾移植研究。

生物活性

Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation.

性状

Liquid

IC50 & Target[1][2]

Interleukin-2 receptor

体外研究(In Vitro)

Basiliximab specifically inhibits T lymphocyte proliferation by binding to the IL-2Rα.
Basiliximab binds only to activated lymphocytes and macrophages/monocytes.
Basiliximab does not affect resting T lymphocytes that do not express IL-2Rα. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Basiliximab (CHI 621) (0.07 mg/rat; i.v.; once) decreases total placental natural killer cells in reduced uterine perfusion pressure (RUPP) rats. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. McKeage K, et al. Basiliximab: a review of its use as induction therapy in renal transplantation. BioDrugs. 2010 Feb 1;24(1):55-76.
[2]. Cunningham M W, et al. The Role of Interleukin‐2 (IL‐2) in Natural Killer Cell (NK) Activation and Hypertension in a Preclinical Rat Model of Preeclampsia. The FASEB Journal, 2018, 32: 911.1-911.1.
[3]. Chapman TM, et

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Data Sheet

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