CC-90002|2085844-54-6|-陌孚医药/Medlife

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CC-90002

目录号: PL13344 纯度: ≥96%

CAS No. :2085844-54-6

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中文名称	CC-90002
英文名称	CC-90002
英文别名	INBRX 103;CC-90002
Cas No.	2085844-54-6
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

CC-90002 是一种人源化抗 CD47 单克隆抗体 (mAb)。CC-90002 与 CD47 具有高亲和力，具有亚纳摩尔 K_d 值。CC-90002 可用于血液系统恶性肿瘤和实体瘤的研究。

生物活性

CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar K d value. CC-90002 can be used for the research of hematologic malignancies and solid tumors.

性状

Liquid

体外研究(In Vitro)

CC-90002 has a high affinity for binding to CD47 with a subnanomolar dissociation constant (Kd) value.
CC-90002 can block the CD47-SIRPa interaction with IC50 value in the subnanomolar range.
CC-90002 has inhibitory effect in concentration-dependent in the ALL and AML cell lines. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

CC-90002 shows significant dose-dependent antitumor activity and significant tumor regression in tumor xenografts models. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Rama Krishna Narla, et al. The humanized anti-CD47 monclonal antibody, CC-90002, has antitumor activity in vitro and in vivo.
[2]. Zhongxing Jiang, et al. Targeting CD47 for cancer immunotherapy. J Hematol Oncol. 2021 Oct 30;14(1):180.

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