PEG400 (Synonyms: 聚乙二醇400; Polyethylene glycol 400)
目录号: PL13165 纯度: N/A
CAS No. :25322-68-3
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中文名称
PEG400
中文别名
聚氧乙烯400;聚乙二醇400;PEG400;PEG
英文名称
PEG400
Cas No.
25322-68-3
分子式
Ho(CH2CH2O)NH
包装储存
Pure form -20°C 3 years;4°C 2 years
产品详情
PEG400 是一种强亲水性聚乙二醇,可作为物质的优良溶剂。PEG400 广泛用于各种药物制剂中。
生物活性
PEG400 is a strongly hydrophilic polyethylene glycol used as an excellent solvent for a large number of substances. PEG400 is widely used in a variety of pharmaceutical formulations.
性状
Liquid
体内研究(In Vivo)
Treatment of Fischer 344 rats with PEG400 at a constant volume of 1.0, 2.5 or 5.0 mL/kg body weight/day 5 days/wk for 13 week does not result in any mortality attributed to chemical toxicity or changes in haematology or clinical chemistry findings.
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
The final concentration of PEG300 can go up to 50% in the formulations for intravenous and intramuscular injection without any toxic effects. In PEG400 based solubility-enabling formulations in oral delivery of lipophilic drugs, both the 60% and the 100% PEG-400 formulations allowed full solubilization of the dose throughout the entire gastrointestinal tract-like journey.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years;4°C 2 years
参考文献
[1]. Hermansky SJ, et al. Effects of polyethylene glycol 400 (PEG 400) following 13 weeks of gavage treatment in Fischer-344 rats. Food Chem Toxicol. 1995 Feb;33(2):139-49.
[2]. Xiaoqin Wang, et al. Injectable silk-polyethylene glycol hydrogels. Acta Biomater. 2015 Jan;12:51-61.
[3]. Avital Beig, et al. Striking the
溶解度数据
In Vitro: H2O : 100 mg/mL (Need ultrasonic)DMSO : 100 mg/mL (Need ultrasonic)
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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