GSK2798745|1419609-94-1|-陌孚医药/Medlife

您当前的位置：

GSK2798745

目录号: PL12473 纯度: ≥99%

CAS No. :1419609-94-1

商品编号	规格	价格	会员价
PL12473-5mg	5mg	¥8592.73	请登录
PL12473-10mg	10mg	¥15454.55	请登录
PL12473-50mg	50mg	¥46363.64	请登录
PL12473-100mg	100mg	询价	询价
PL12473-200mg	200mg	询价	询价
PL12473-10mM*1mLinDMSO	10mM*1mLinDMSO	¥9452.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	GSK2798745
中文别名	1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile
英文名称	GSK2798745
英文别名	1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile;GSK2798745;63FJ7LF55O;URCMKDJBULWNAI-DQEYMECFSA-N;3-[[(5S,7S)-3-[5-(2-Hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl];3-[[(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl]methyl]benzimidazole-5-carbonitrile;BDBM50502640;AT16701;1-(((5S,7S)-3-(5-(2-Hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro(4.5)decan-7-yl)methyl)-1hbenzo(d)imidazole-6-carbonitrile;1-(((5S,7S)-3-(5-(2-hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-az;Unii-63FJ7LF55O
Cas No.	1419609-94-1
分子式	C₂₅H₂₈N₆O₃
分子量	460.53
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

GSK2798745 是一种强效的、选择性的且具有口服活性的瞬时受体电位香草酸 4 (TRPV4) 离子通道阻断剂，对 hTRPV4 和 rTRPV4 的 IC₅₀ 值分别为 1.8 和 1.6 nM。GSK2798745 可用于心脏和呼吸系统疾病研究。

生物活性

GSK2798745 is a potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC 50 s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 can be used in cardiac and respiratory diseases research.

性状

Solid

IC50 & Target[1][2]

IC50: 1.8 nM (hTRPV4) and 1.6 nM (rTRPV4)

体外研究(In Vitro)

GSK2798745 inhibits TRPV4 agonist-induced impedance reduction in human umbilical vein endothelial cells (HUVECs). has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

GSK2798745 inhibits TRPV4 agonist-mediated lung edema in rats in a dose-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: TRPV4-mediated lung edema in male Sprague-Daw

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Goyal N, et al. Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects. Am J Cardiovasc Drugs. 2019 Jun;19(3):335-342.
[2]. Brooks CA, et al. Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4). ACS Med Chem Lett. 2019 Jul 15;10(8):1228-1233.

溶解度数据	In Vitro: DMSO : 250 mg/mL (542.85 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation